Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase
about
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationshipsInhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1Predicting resistance mutations using protein design algorithmsStructure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductaseToward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenesElucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate ReductasePropargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosisAntifolate agents: a patent review (2006 - 2010).Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Protein design algorithms predict viable resistance to an experimental antifolateProspective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistanceSynthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis.Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based AntibioticsMicrowave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based AntibioticsCrystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.Winning the arms race by improving drug discovery against mutating targets.OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.The potential role of trimethoprim-sulfamethoxazole in the treatment of drug-resistant tuberculosis.Antibacterial Antifolates: From Development through Resistance to the Next GenerationEmergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe.MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance.The challenge of developing robust drugs to overcome resistance.
P2860
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P2860
Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase
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2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Towards the understanding of r ...... aureus dihydrofolate reductase
@ast
Towards the understanding of r ...... aureus dihydrofolate reductase
@en
Towards the understanding of r ...... aureus dihydrofolate reductase
@nl
type
label
Towards the understanding of r ...... aureus dihydrofolate reductase
@ast
Towards the understanding of r ...... aureus dihydrofolate reductase
@en
Towards the understanding of r ...... aureus dihydrofolate reductase
@nl
prefLabel
Towards the understanding of r ...... aureus dihydrofolate reductase
@ast
Towards the understanding of r ...... aureus dihydrofolate reductase
@en
Towards the understanding of r ...... aureus dihydrofolate reductase
@nl
P2093
P2860
P3181
P1476
Towards the understanding of r ...... aureus dihydrofolate reductase
@en
P2093
Amy C Anderson
Dennis L Wright
Kathleen M Frey
Michael N Lombardo
P2860
P3181
P356
10.1016/J.JSB.2009.12.011
P577
2010-04-01T00:00:00Z