Structural discovery of small molecule binding sites in Cu-Zn human superoxide dismutase familial amyotrophic lateral sclerosis mutants provides insights for lead optimization

Structural discovery of small molecule binding sites in Cu-Zn human superoxide dismutase familial amyotrophic lateral sclerosis mutants provides insights for lead optimization

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http://www.wikidata.org/entity/Q27658931
Ligand binding and aggregation of pathogenic SOD1Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral SclerosisParsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Modulating protein-protein interactions with small molecules: the importance of binding hotspots.Unmet challenges of structural genomicsLipid-associated aggregate formation of superoxide dismutase-1 is initiated by membrane-targeting loops.A prion-like mechanism for the propagated misfolding of SOD1 from in silico modeling of solvated near-native conformersQuercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant.Pentachlorophenol molecule design with lower bioconcentration through 3D-QSAR associated with molecule docking.Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism
P2860

Structural discovery of small molecule binding sites in Cu-Zn human superoxide dismutase familial amyotrophic lateral sclerosis mutants provides insights for lead optimization

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http://www.wikidata.org/entity/Q27658931
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2010 nî lūn-bûn
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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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type
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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Structural discovery of small ...... insights for lead optimization
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P2093
P304
P31
P3181
P356
P407
P433
P478
P577
P698
P921