Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins
about
Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liverProbing serpin reactive-loop conformations by proteolytic cleavageThromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational diseaseStructural mechanism for the carriage and release of thyroxine in the blood.Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpinsPepsin-inhibitory activity of the uterine serpinsTopography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational diseaseCrystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibitionCrystal structure of neuroserpin: a neuronal serpin involved in a conformational diseaseThe refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsCrystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loopIdentification and characterization of a novel rat ov-serpin family member, trespinA redox-sensitive loop regulates plasminogen activator inhibitor type 2 (PAI-2) polymerizationFormation of the covalent chymotrypsin.antichymotrypsin complex involves no large-scale movement of the enzyme.The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.A novel mode of polymerization of alpha1-proteinase inhibitor.Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopyStructural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model buildingSmoothing a rugged protein folding landscape by sequence-based redesign.Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular DiseaseCharacterization of carbohydrate chains of C1-inhibitor and of desialylated C1-inhibitor.The conversion of active to latent plasminogen activator inhibitor-1 is an energetically silent event.Regulation of proteolytic activity in tissues.The mechanism by which serpins inhibit thrombin and other serine proteinases.Structural aspects of serpin inhibition.Interaction of activated protein C with serpins.Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.The mechanism of fibril formation of a non-inhibitory serpin ovalbumin revealed by the identification of amyloidogenic core regions.The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin.Probing the local conformational change of alpha1-antitrypsin.Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila.Tomato cystatin SlCYS8 as a stabilizing fusion partner for human serpin expression in plants.Significance of secondary structure predictions on the reactive center loop region of serpins: a model for the folding of serpins into a metastable state.Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate.alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema.A Kinetic Mechanism for the Polymerization of α1-Antitrypsin
P2860
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P2860
Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins
description
1991 nî lūn-bûn
@nan
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Crystal structure of cleaved h ...... comparison with other serpins
@ast
Crystal structure of cleaved h ...... comparison with other serpins
@en
Crystal structure of cleaved h ...... comparison with other serpins
@nl
type
label
Crystal structure of cleaved h ...... comparison with other serpins
@ast
Crystal structure of cleaved h ...... comparison with other serpins
@en
Crystal structure of cleaved h ...... comparison with other serpins
@nl
prefLabel
Crystal structure of cleaved h ...... comparison with other serpins
@ast
Crystal structure of cleaved h ...... comparison with other serpins
@en
Crystal structure of cleaved h ...... comparison with other serpins
@nl
P2093
P3181
P1476
Crystal structure of cleaved h ...... comparison with other serpins
@en
P2093
P304
P3181
P356
10.1016/0022-2836(91)90704-A
P407
P577
1991-04-05T00:00:00Z