Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors
about
Advances in targeting cyclic nucleotide phosphodiesterasesSynthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET.Phosphodiesterase 10A inhibitors: a 2009 - 2012 patent update.Phosphodiesterase 10A inhibitors: analysis of US/EP patents granted since 2012.Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.Computational determination of binding structures and free energies of phosphodiesterase-2 with benzo[1,4]diazepin-2-one derivatives.Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.Composite multi-parameter ranking of real and virtual compounds for design of MC4R agonists: renaissance of the Free-Wilson methodology.Particle swarm optimization and genetic algorithm as feature selection techniques for the QSAR modeling of imidazo[1,5-a]pyrido[3,2-e]pyrazines, inhibitors of phosphodiesterase 10A.Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia.Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005.
P2860
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P2860
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
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Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@ast
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
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Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
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type
label
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@ast
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@en
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@nl
prefLabel
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@ast
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@en
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@nl
P2093
P356
P1476
Discovery of imidazo[1,5-a]pyr ...... sphodiesterase 10A inhibitiors
@en
P2093
Barbara Langen
Boyd L Harrison
Christian Grunwald
Hans Stange
Hans-Joachim Lankau
Karen L Marquis
Menelas N Pangalos
Michael S Malamas
Nicholas J Brandon
Norbert Höfgen
P304
P356
10.1021/JM1002793
P407
P577
2010-06-10T00:00:00Z