Structural Basis for Conformational Dynamics of GTP-bound Ras Protein - Wikidata - awgldk - TriplyDB

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

http://www.wikidata.org/entity/Q27661719

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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants Mining electron density for functionally relevant protein polysterism in crystal structures.H-Ras forms dimers on membrane surfaces via a protein-protein interface.Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein The role of conserved waters in conformational transitions of Q61H K-ras.Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.Death pathways triggered by activated Ras in cancer cells A switch I mutant of Cdc42 exhibits less conformational freedom.Small-molecule modulation of Ras signaling.Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.Pocket-based drug design: exploring pocket space Specific Conformational States of Ras GTPase upon Effector Binding The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.Therapeutic Approaches to RAS Mutation.Lessons from computer simulations of Ras proteins in solution and in membrane Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Current status of the development of Ras inhibitors.Direct Modulation of Small GTPase Activity and Function.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.High pressure 31P NMR spectroscopy on guanine nucleotides.Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.Relation between the conformational heterogeneity and reaction cycle of Ras: molecular simulation of Ras.A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activation.¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.Large scale analysis of protein conformational transitions from aqueous to non-aqueous media.RAS variant signalling Structural dynamics of translation elongation factor Tu during aa-tRNA delivery to the ribosome E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

http://www.wikidata.org/entity/Q27661719

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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type

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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prefLabel

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

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JBC.M110.125161

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Journal of Biological Chemistry

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Structural basis for conformational dynamics of GTP-bound Ras protein

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Fumi Shima

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Jingling Liao

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Kousuke Matsumoto

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Masaki Yamamoto

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Min Ye

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Mitsugu Araki

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Naoki Yamamoto

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Shin Muraoka

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Takeshi Sugimoto

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Tohru Kataoka

http://www.w3.org/2001/XMLSchema#string

P2860

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

Dynamic properties of the Ras switch I region and its importance for binding to effectors

Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42

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22696-22705

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1626801

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10.1074/JBC.M110.125161

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29

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285

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Takashi Kumasaka

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