The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site
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Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formationProteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesisEpigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "in vivo" evidence from FAP mice modelsNovel drugs targeting transthyretin amyloidosis.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG.Green tea halts progression of cardiac transthyretin amyloidosis: an observational reportIdentification of Transthyretin Fibril Formation Inhibitors Using Structure-Based Virtual Screening.Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption.Natural biomolecules and protein aggregation: emerging strategies against amyloidogenesisNatural compounds may open new routes to treatment of amyloid diseasesProtein folding and aggregation into amyloid: the interference by natural phenolic compoundsFBS or BSA Inhibits EGCG Induced Cell Death through Covalent Binding and the Reduction of Intracellular ROS Production.Green Tea Polyphenols in drug discovery - a success or failure?Clearance of extracellular misfolded proteins in systemic amyloidosis: experience with transthyretin.Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical.Beneficial properties of natural phenols: highlight on protection against pathological conditions associated with amyloid aggregation.Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.The self-interaction of native TDP-43 C terminus inhibits its degradation and contributes to early proteinopathies.Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids in Pseudomonas aeruginosa and Increases Biofilm Susceptibility to Antibiotic Treatment.The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism.Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains.Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors.Influence of EGCG on α-synuclein (αS) aggregation and identification of their possible binding mode: A computational study using molecular dynamics simulation.Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds.Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies
P2860
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P2860
The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The crystal structure of the g ...... rom the thyroxine binding site
@ast
The crystal structure of the g ...... rom the thyroxine binding site
@en
The crystal structure of the g ...... rom the thyroxine binding site
@nl
type
label
The crystal structure of the g ...... rom the thyroxine binding site
@ast
The crystal structure of the g ...... rom the thyroxine binding site
@en
The crystal structure of the g ...... rom the thyroxine binding site
@nl
prefLabel
The crystal structure of the g ...... rom the thyroxine binding site
@ast
The crystal structure of the g ...... rom the thyroxine binding site
@en
The crystal structure of the g ...... rom the thyroxine binding site
@nl
P2093
P3181
P356
P1433
P1476
The crystal structure of the g ...... rom the thyroxine binding site
@en
P2093
Hirofumi Kai
Hiroshi Morioka
Mami Chirifu
Mamiko Momohara
Mary Ann Suico
Masanori Miyata
Mineyuki Mizuguchi
Misato Sho
Miyuki Kugimiya
Saori Morino-Koga
P304
P3181
P356
10.1021/BI1004409
P407
P577
2010-07-27T00:00:00Z