A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex Interactions
about
MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNAEmerging critical roles of Fe-S clusters in DNA replication and repair.Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation.Recent advances in the structural mechanisms of DNA glycosylasesGenome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility.SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clampAssociation of the Rad9-Rad1-Hus1 checkpoint clamp with MYH DNA glycosylase and DNA.Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage.Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.Understanding the role of the Q338H MUTYH variant in oxidative damage repairCoordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeastMechanisms of base substitution mutagenesis in cancer genomes.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Genetic instability in lymphoblastoid cell lines expressing biallelic and monoallelic variants in the human MUTYH gene.Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.Dispensability of the [4Fe-4S] cluster in novel homologues of adenine glycosylase MutY.A zinc linchpin motif in the MUTYH glycosylase interdomain connector is required for efficient repair of DNA damage.A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells.Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues.A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] cluster
P2860
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P2860
A Structural Hinge in Eukaryotic MutY Homologues Mediates Catalytic Activity and Rad9–Rad1–Hus1 Checkpoint Complex Interactions
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@ast
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@en
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@nl
type
label
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@ast
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@en
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@nl
prefLabel
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@ast
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@en
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@nl
P2093
P2860
P1476
A Structural Hinge in Eukaryot ...... heckpoint Complex Interactions
@en
P2093
Amrita Madabushi
Dau-Yin Chang
Dimeka N Patterson
Eric A Toth
Jade Bernstein
Paz J Luncsford
P2860
P304
P356
10.1016/J.JMB.2010.08.045
P407
P577
2010-10-29T00:00:00Z