An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA - Wikidata - awgldk - TriplyDB

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

http://www.wikidata.org/entity/Q27664845

about

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S - and R -6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors Development of Antisense Drugs for Dyslipidemia.Antisense drug discovery and development.Synthesis and properties of novel 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids with exocyclic methylene groups.Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals.Biological applications of xeno nucleic acids.TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue Synthesis of 2',4'-bridged nucleosides using a new orthogonally protected sugar synthon: 5-O-(tert-butyldiphenylsilyl)-4-C-hydroxymethyl-1,2-O-isopropylidene-3-O-napthyl-α-D-allofuranose.Synthesis and properties of 2'-O,4'-C-spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2',4'-BNA/LNA bearing a cyclopropane ring.Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units Organische Chemie 2010

P2860

Q27673978-377E3CB0-54F4-4404-AF5D-EAED14A29EBB Q27676643-30A778FA-A58C-4119-AAD2-D42F5F572C7D Q27679106-BF5B4F99-8C11-48F3-AEAD-893EFFB2A03A Q27710131-776F04CB-DC42-489F-94F9-64637697C1C3 Q28828761-3885CD30-6D1D-483C-BD80-DCCB1E6AF281 Q33992677-4E303D8B-B768-4EB8-A5B3-A700B890CB39 Q36296557-DB0E9EAC-E898-4EEB-87E8-9521C2289406 Q37387192-7A378E86-C08A-4455-A71F-618C11C54C98 Q37859009-629177C8-7ECA-4F5D-85DA-D10E902DF0DA Q38290684-F03ADE3B-8240-4E3D-83E3-25A80616EA78 Q38318293-BD01E851-4F20-41A1-9740-EAC5AF940A78 Q39003630-B1D81E1F-6389-428A-B31B-B2BD46E71401 Q39370899-64072D60-43C3-4012-89FB-91D3F95B595F Q41832597-F8353826-0B50-4562-AB69-9174AB6AFADE Q42158300-806B4A44-FEC1-4166-BF78-A85F27A125EE Q45124005-5722BE9F-128D-482D-8457-195655CA24C2 Q47703250-1D8AB2FB-457F-4C8E-934D-033984074805 Q56791584-287B6EAF-6AA7-47F6-91E5-51C8494EE31A Q57742701-2DB2B873-85E6-4675-AC2D-C05853119894

P2860

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

http://www.wikidata.org/entity/Q27664845

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@ast

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@en

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@nl

type

label

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@ast

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@en

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@nl

prefLabel

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@ast

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@en

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@nl

P1433

Q27664845-EF735E8D-907F-4674-A8AF-003372302003

P1476

Q27664845-A539846F-2C35-4CCC-9B0A-B515FF27F8E8

P2093

Q27664845-2F4EEBCC-C96C-4A59-946E-56630F546691

Q27664845-40BDBD68-A307-43C2-BE25-18B29ADFFA74

Q27664845-46255995-3296-4623-B844-72008A7CF07F

Q27664845-A403EC8D-B52E-4D2E-BC75-830474A95342

Q27664845-A622698D-3035-411F-AF4B-B9A2FC72E202

Q27664845-C54855A6-ACFD-4C5A-9B32-4EDEDD0C5DF5

Q27664845-C8B0C4C8-AD24-4F9A-BC67-0BBFC31B93FA

Q27664845-DB74BE58-5A80-4A99-8487-57EC2FAA8438

Q27664845-ED9A0B1A-6113-4E62-A1E6-7514BD211334

P2860

Q27664845-010E8A04-B782-4108-9A22-CCECA7780DF4

Q27664845-0544CEAF-58E4-43E7-B186-41AABAF127D5

Q27664845-0E6D1E18-E28B-4CD1-A2BE-A302A2CE378F

Q27664845-15C49176-05AF-4D2F-B230-5F7EA8983D03

Q27664845-1B2037D8-B417-4547-A428-B0C4EAC02C4E

Q27664845-2F4438E5-5A93-47BC-9F33-0C95FCA0DCA9

Q27664845-36EA1DA9-2D27-4C2D-AF80-0459D1946357

Q27664845-3B2F06D6-2F4C-4ECB-84BC-072F9C2F569F

Q27664845-3D10D69F-EFC4-4910-B825-03D78492CECF

Q27664845-521D2A98-AFE6-40EB-AA77-418096E7C788

P304

Q27664845-592C5B0C-F53D-4E39-871B-3E12CA094A14

P31

Q27664845-15A0035C-DDF5-46FE-A348-39BDB5DA0D7F

P3181

Q27664845-7560A516-E424-4142-BA24-A2C51DA35C6F

P356

Q27664845-C8C9A45C-6C0E-4B0B-ABCE-0CC13ECB52AC

P407

Q27664845-3ECA1F1F-0A8C-4BA8-9518-5667DC654AB2

P433

Q27664845-201BF036-5F65-49FC-9C5D-DBA309113B06

P478

Q27664845-F85A6D2C-C2C3-4C7A-B755-BC891E93A932

P50

Q27664845-94C1AE97-9AB0-4D74-85B0-C629FDFBC7D6

P577

Q27664845-09016E65-16E2-4BF4-B556-67750DFC3299

P5875

Q27664845-CF5724B8-9467-42B4-9526-D28B338DACE8

P698

Q27664845-AA6DBC35-8F2F-483F-9751-7FACBF9AAD3E

P921

Q27664845-1B932A41-F6C6-4147-BFA9-C4B4DEC897AD

P932

Q27664845-8584C721-4922-42C9-AF31-4662AFF5BA5B

P3181

P356

P1433

Journal of the American Chemical Society

P1476

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

@en

P2093

Andres Berdeja

http://www.w3.org/2001/XMLSchema#string

Andrew Siwkowski

http://www.w3.org/2001/XMLSchema#string

Andrew T Watt

http://www.w3.org/2001/XMLSchema#string

Charles R Allerson

http://www.w3.org/2001/XMLSchema#string

Eric E Swayze

http://www.w3.org/2001/XMLSchema#string

Hans Gaus

http://www.w3.org/2001/XMLSchema#string

Pradeep S Pallan

http://www.w3.org/2001/XMLSchema#string

Punit P Seth

http://www.w3.org/2001/XMLSchema#string

Thazha P Prakash

http://www.w3.org/2001/XMLSchema#string

P2860

Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-alpha-hm-dT).

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease.

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

2'-Modified oligonucleotides for antisense therapeutics.

Potent inhibition of microRNA in vivo without degradation

P304

14942-50

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4281453

http://www.w3.org/2001/XMLSchema#string

P356

10.1021/JA105875E

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

132

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-10-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47297410

http://www.w3.org/2001/XMLSchema#string

P698

20886816

http://www.w3.org/2001/XMLSchema#string

P921

P932

2993159

http://www.w3.org/2001/XMLSchema#string