The structural basis for membrane binding and pore formation by lymphocyte perforin
about
The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assemblyRapid assembly of a multimeric membrane protein porePeptidylarginine Deiminases as Drug Targets in Neonatal Hypoxic-Ischemic EncephalopathyCytotoxic granule secretion by lymphocytes and its link to immune homeostasisObstructing toxin pathways by targeted pore blockagePutting the structure into complementVisualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BConformational changes during pore formation by the perforin-related protein pleurotolysinHigh-density grids for efficient data collection from multiple crystalsMelanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapseStructural basis of complement membrane attack complex formation.Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59Phosphoinositide-mediated oligomerization of a defensin induces cell lysisDefining the interaction of perforin with calcium and the phospholipid membraneCrystal structure of listeriolysin O reveals molecular details of oligomerization and pore formationCalcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasitesKilling of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer ProteinsStructure of the poly-C9 component of the complement membrane attack complexStructural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid MembranesCytotoxic proteins and therapeutic targets in severe cutaneous adverse reactionspH dependence of listeriolysin O aggregation and pore-forming abilityInflammasome-activated gasdermin D causes pyroptosis by forming membrane poresOperation of the Australian Store.Synchrotron for macromolecular crystallographyPerforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytesGranzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.The Apicomplexan CDC/MACPF-like pore-forming proteins.Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins.Membrane assembly of the cholesterol-dependent cytolysin pore complex.Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients.An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.Perforin rapidly induces plasma membrane phospholipid flip-flopA novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within EuteleostomiHigh-throughput sequence analysis of turbot (Scophthalmus maximus) transcriptome using 454-pyrosequencing for the discovery of antiviral immune genes.Effects of MACPF/CDC proteins on lipid membranes.Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome CPerforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
P2860
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P2860
The structural basis for membrane binding and pore formation by lymphocyte perforin
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The structural basis for membrane binding and pore formation by lymphocyte perforin
@ast
The structural basis for membrane binding and pore formation by lymphocyte perforin
@en
The structural basis for membrane binding and pore formation by lymphocyte perforin
@nl
type
label
The structural basis for membrane binding and pore formation by lymphocyte perforin
@ast
The structural basis for membrane binding and pore formation by lymphocyte perforin
@en
The structural basis for membrane binding and pore formation by lymphocyte perforin
@nl
prefLabel
The structural basis for membrane binding and pore formation by lymphocyte perforin
@ast
The structural basis for membrane binding and pore formation by lymphocyte perforin
@en
The structural basis for membrane binding and pore formation by lymphocyte perforin
@nl
P2093
P50
P921
P3181
P356
P1433
P1476
The structural basis for membrane binding and pore formation by lymphocyte perforin
@en
P2093
Annette Ciccone
Helen R Saibil
Ilia Voskoboinik
Katherine Baran
Kylie A Browne
Michael J Kuiper
Michelle A Dunstone
Natalya Lukoyanova
Ruby H P Law
Sandra Verschoor
P2888
P304
P3181
P356
10.1038/NATURE09518
P407
P50
P577
2010-11-18T00:00:00Z
P5875
P6179
1051929930