about
Principles of antibody-mediated TNF receptor activationFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinitySubversion of cytokine networks by virally encoded decoy receptorsStructural Basis for Treating Tumor Necrosis Factor (TNF )-associated Diseases with the Therapeutic Antibody InfliximabS-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXSComparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular ViewDimerization of LT R by LT 1 2 is necessary and sufficient for signal transductionMechanistic Basis for Functional Promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 AssemblyA novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments.Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy.Are different stoichiometries feasible for complexes between lymphotoxin-alpha and tumor necrosis factor receptor 1?Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily membersThe transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity.Small-molecule inhibitors of the interaction between TNF and TNFR.Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.Medicine. Progranulin resolves inflammationThree TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.Binding efficiency of protein-protein complexes.Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection.Development of novel drug delivery systems using phage display technology for clinical application of protein drugsTNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.Human and mouse CD137 have predominantly different binding CRDs to their respective ligandsConserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in FishPolymorphisms in the tumor necrosis factor receptor genes affect the expression levels of membrane-bound type I and type II receptors.How vaccinia virus has evolved to subvert the host immune response.Regulation of TNF-α with a focus on rheumatoid arthritis.Current approaches to fine mapping of antigen-antibody interactions.Functionality of Intrinsic Disorder in Tumor Necrosis Factor-α and its Receptors.Biologics beyond TNF-α inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders.TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2.Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.Inflammatory osteolysis: a conspiracy against bone.Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.Rational design of TNFα binding proteins based on the de novo designed protein DS119.The structure-function relationship of disulfide bonds in etanercept.Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique.Reconstructing the discontinuous and conformational β1/β3-loop binding site on hFSH/hCG by using highly constrained multicyclic peptides.Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Solution of the structure of the TNF-TNFR2 complex
@ast
Solution of the structure of the TNF-TNFR2 complex
@en
Solution of the structure of the TNF-TNFR2 complex
@nl
type
label
Solution of the structure of the TNF-TNFR2 complex
@ast
Solution of the structure of the TNF-TNFR2 complex
@en
Solution of the structure of the TNF-TNFR2 complex
@nl
prefLabel
Solution of the structure of the TNF-TNFR2 complex
@ast
Solution of the structure of the TNF-TNFR2 complex
@en
Solution of the structure of the TNF-TNFR2 complex
@nl
P2093
P3181
P1433
P1476
Solution of the structure of the TNF-TNFR2 complex
@en
P2093
Mai Yoshikawa
Shinsaku Nakagawa
Teruya Nakamura
Yasuo Tsutsumi
Yasuo Yoshioka
Yohei Mukai
Yuriko Yamagata
P3181
P356
10.1126/SCISIGNAL.2000954
P577
2010-11-16T00:00:00Z