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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

http://www.wikidata.org/entity/Q27666241

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Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase An octamer of enolase from Streptococcus suis Structure of New Delhi metallo-β-lactamase 1 (NDM-1)Biochemical characteristics of New Delhi metallo-β-lactamase-1 show unexpected difference to other MBLs Discovery of novel new Delhi metallo-β-lactamases-1 inhibitors by multistep virtual screening Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30.Molecular basis of NDM-1, a new antibiotic resistance determinant Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating structural features between B1 types.Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Probing the effect of the non-active-site mutation Y229W in New Delhi metallo-β-lactamase-1 by site-directed mutagenesis, kinetic studies, and molecular dynamics simulations.B1-Metallo-β-Lactamases: Where Do We Stand?Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.Crystal structures reveal metal-binding plasticity at the metallo-β-lactamase active site of PqqB from Pseudomonas putida.Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria Progress toward inhibitors of metallo-β-lactamases.New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers.Inhibition of New Delhi Metallo-β-Lactamase 1 (NDM-1) Producing Escherichia coli IR-6 by Selected Plant Extracts and Their Synergistic Actions with Antibiotics.Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.Danger lurking in the "unknowns": structure-to-function studies of hypothetical protein Bleg1_2437 from Bacillus lehensis G1 alkaliphile revealed an evolutionary divergent B3 metallo-beta-lactamase.Inhibitor discovery of full-length New Delhi metallo-β-lactamase-1 (NDM-1).Refined models of New Delhi metallo-beta-lactamase-1 with inhibitors: an QM/MM modeling study.Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.Assay platform for clinically relevant metallo-β-lactamases.Studies on New Delhi Metallo-Beta-Lactamse-1 producing Acinetobacter baumannii isolated from donor swab in a tertiary eye care centre, India and structural analysis of its antibiotic binding interactions.A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity Exploring skyline for both MS(E) -based label-free proteomics and HRMS quantitation of small molecules.Real-time monitoring of New Delhi metallo-β-lactamase activity in living bacterial cells by 1H NMR spectroscopy.Effective antimicrobial activity of Cbf-K16 and Cbf-A7 A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro.Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.Structural and functional insight of New Delhi Metallo β-lactamase-1 variants.Zinc ion-induced conformational changes in new Delphi metallo-β-lactamase 1 probed by molecular dynamics simulations and umbrella sampling.Bacterial zincophore [S,S]-ethylenediamine-N,N'-disuccinic acid is an effective inhibitor of MBLs.Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens.Real-time activity monitoring of New Delhi metallo-β-lactamase-1 in living bacterial cells by UV-Vis spectroscopy.Biomolecular logic gate for analysis of the New Delhi metallo-β-lactamase (NDM)-coding gene with concurrent determination of its drug resistance-encoding fragments.Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids.A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1.Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

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P2860

A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

http://www.wikidata.org/entity/Q27666241

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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type

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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Cheng Yang

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Guojun Niu

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Honggang Zhou

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Jing Wang

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Wenqing Shui

http://www.w3.org/2001/XMLSchema#string

Yaozhou Zhang

http://www.w3.org/2001/XMLSchema#string

Yu Guo

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Yuna Sun

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Zhiyong Lou

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Zihe Rao

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The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India

PROCHECK: a program to check the stereochemical quality of protein structures

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Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor

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