A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors

A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors

Item
http://www.wikidata.org/entity/Q27666430
Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsFragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry ExplorationFragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.Replacing sulfa drugs with novel DHPS inhibitorsNovel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2).Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials.An overview of phenylcyclopropylamine derivatives: biochemical and biological significance and recent developments.Investigation of the binding mode of 1, 3, 4-oxadiazole derivatives as amide-based inhibitors for soluble epoxide hydrolase (sEH) by molecular docking and MM-GBSA.Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screeningFormation of activity cliffs is accompanied by systematic increases in ligand efficiency from lowly to highly potent compounds.Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors.Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.Ligand Efficiency Outperforms pIC50 on Both 2D MLR and 3D CoMFA Models: A Case Study on AR Antagonists.Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment.
P2860

A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors

Item
http://www.wikidata.org/entity/Q27666430
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@ast
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@en
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@nl
type
label
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@ast
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@en
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@nl
prefLabel
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@ast
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@en
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
A practical use of ligand effi ...... e epoxide hydrolase inhibitors
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698