Crystal Structure and Allosteric Activation of Protein Kinase C βII
about
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Retinol as electron carrier in redox signaling, a new frontier in vitamin A researchDynamics and Membrane Interactions of Protein Kinase CRegulation of protein kinases by lipidsLocalization and quaternary structure of the PKA RI holoenzymeCrystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain CommunicationStructural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymesProtein kinase C mechanisms that contribute to cardiac remodellingA molecular ruler regulates cytoskeletal remodelling by the Rho kinasesThe C-terminal V5 domain of Protein Kinase Cα is intrinsically disordered, with propensity to associate with a membrane mimeticCoordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.Zinc-binding cysteines: diverse functions and structural motifs.Molecular dynamics approach to probe PKCβII-ligand interactions and influence of crystal water molecules on these interactions.MultiBac complexomics.Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-αC2-domain mediated nano-cluster formation increases calcium signaling efficiency.Conserved modular domains team up to latch-open active protein kinase CαCharge density influences C1 domain ligand affinity and membrane interactionsAnomalous diffraction in crystallographic phase evaluationATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibitionInteractions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligandsPhosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity.Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancerGeneration and characterization of ATP analog-specific protein kinase Cδ.Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals.Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyThe C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ ActivityFormation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS).Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement.Chloride Channel 3 Channels in the Activation and Migration of Human Blood Eosinophils in Allergic Asthma.C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosisProtein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changesRegulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway
P2860
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P2860
Crystal Structure and Allosteric Activation of Protein Kinase C βII
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@ast
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@en
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@nl
type
label
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@ast
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@en
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@nl
prefLabel
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@ast
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@en
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@nl
P2860
P50
P3181
P1433
P1476
Crystal Structure and Allosteric Activation of Protein Kinase C βII
@en
P2093
James H Hurley
Layla F Saidi
P2860
P3181
P356
10.1016/J.CELL.2010.12.013
P407
P577
2011-01-07T00:00:00Z