The structural basis for tight control of PP2A methylation and function by LCMT-1.
about
Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage responseFree fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolismThe biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificityCircumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signalingMechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylationStructural basis of protein phosphatase 2A stable latencyStructure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylationStructural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone.Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.The Basic Biology of PP2A in Hematologic Cells and MalignanciesTBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityAltered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease.Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent mannerInsights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure.Single-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme accessAdipose tissue-liver axis in alcoholic liver disease.PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation.Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus.Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cellsDysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies.Phosphoinositide 3-kinase γ inhibits cardiac GSK-3 independently of Akt.Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues.PP2A as a master regulator of the cell cycle.Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options.Regulation of Cell Division.Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aα catalytic subunitRegulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes.Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast.Methylation-regulated decommissioning of multimeric PP2A complexes.S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.A Metabolic Function for Phospholipid and Histone Methylation.Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells.Cornel Iridoid Glycoside Inhibits Tau Hyperphosphorylation via Regulating Cross-Talk Between GSK-3β and PP2A Signaling.NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
P2860
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P2860
The structural basis for tight control of PP2A methylation and function by LCMT-1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1
@nl
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@ast
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@en
type
label
The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1
@nl
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@ast
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@en
prefLabel
The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1
@nl
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@ast
The structural basis for tight control of PP2A methylation and function by LCMT-1.
@en
P2093
P2860
P3181
P1433
P1476
The structural basis for tight control of PP2A methylation and function by LCMT-1
@en
P2093
Martin F Semmelhack
Patrick Menden
Philip D Jeffrey
Vitali Stanevich
Yongfeng Li
Yongna Xing
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2010.12.030
P577
2011-02-01T00:00:00Z