Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity
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Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New ScaffoldThe Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein–Protein InteractionsSelectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuationsSmall molecules, big targets: drug discovery faces the protein-protein interaction challenge.Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL.Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.New dimension in therapeutic targeting of BCL-2 family proteins.Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins.Importance of functional groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL.Enrichment of druggable conformations from apo protein structures using cosolvent-accelerated molecular dynamicsDiastereoselective additive trifluoromethylation/halogenation of isoxazole triflones: synthesis of all-carbon-functionalized trifluoromethyl isoxazoline triflonesOrganocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System.NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer.Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL.Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes.Characterization of the stereochemical structures of 2H-thiazolo[3,2-a]pyrimidine compounds and their binding affinities for anti-apoptotic Bcl-2 family proteins.De novo design, synthesis and evaluation of benzylpiperazine derivatives as highly selective binders of Mcl-1.Iodine-mediated regioselective synthesis of vinyl triflones from styrenes with CF3SO2Na.Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents
P2860
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P2860
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@ast
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@en
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@nl
type
label
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@ast
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@en
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@nl
prefLabel
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@ast
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@en
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@nl
P2093
P50
P356
P1476
Quinazoline sulfonamides as du ...... oapoptotic cell-based activity
@en
P2093
Andrew J Souers
Brian J Smith
Guillaume Lessene
Ian P Street
John A Flygare
John P Parisot
Jonathan B Baell
Morey L Smith
P304
P356
10.1021/JM101596E
P407
P577
2011-03-02T00:00:00Z