An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody
about
Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41Cross-neutralization of influenza A viruses mediated by a single antibody loopA Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldCoupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodiesImmunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodiesHuman peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoireNucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.Tissue-specific expressed antibody variable gene repertoiresEpitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergenceHigh Inter-Individual Diversity of Point Mutations, Insertions, and Deletions in Human Influenza Virus Nucleoprotein-Specific Memory B CellsInfluenza virus antigenicity and broadly neutralizing epitopes.Functional consequences of complementarity-determining region deactivation in a multifunctional anti-nucleic acid antibody.Secondary mechanisms of diversification in the human antibody repertoire.Prospects of HA-based universal influenza vaccine.Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity.Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.Predicting antibody complementarity determining region structures without classification.
P2860
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P2860
An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@ast
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@en
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@nl
type
label
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@ast
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@en
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@nl
prefLabel
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@ast
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@en
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@nl
P2860
P50
P356
P1433
P1476
An Insertion Mutation That Dis ...... s Function of a Human Antibody
@en
P2093
Jens C Krause
Patricia B Smith
P2860
P304
P356
10.1128/MBIO.00345-10
P577
2011-01-01T00:00:00Z