Structural basis for CARM1 inhibition by indole and pyrazole inhibitors - Wikidata - awgldk - TriplyDB

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

http://www.wikidata.org/entity/Q27666983

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Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Structural biology and chemistry of protein arginine methyltransferases Design of small molecule epigenetic modulators Current chemical biology approaches to interrogate protein methyltransferases Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Chromatin proteins and modifications as drug targets.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.Chemical biology of protein arginine modifications in epigenetic regulation Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.S-adenosylmethionine-dependent protein methylation is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.Protein Arginine Methylation and Citrullination in Epigenetic Regulation Small Molecule Inhibitors of Protein Arginine Methyltransferases.Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.Metabolic mechanisms of epigenetic regulation.Regulation of transcription factor activity by interconnected post-translational modifications.Targeting protein arginine N-methyltransferases with peptide-based inhibitors: opportunities and challenges.Chromatin modifiers and the promise of epigenetic therapy in acute leukemia Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6).Inhibitors of Protein Methyltransferases and Demethylases.Epigenetics: A primer for clinicians.Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.Targeting histone methylation for colorectal cancer Recent progress in developing selective inhibitors of protein methyltransferases.Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.Inconvenient truths for PRMT6 kinetic studies.Molecular characterization, phylogenetic analysis and expression patterns of five protein arginine methyltransferase genes of channel catfish, Ictalurus punctatus (Rafinesque).Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.Transient Kinetics Define a Complete Kinetic Model for Protein Arginine Methyltransferase 1.Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1.Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011年の論文

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2011年論文

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2011年論文

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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Biochemical Journal

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

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P2093

Ashok V Purandare

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Dianlin Xie

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Gerald J Duke

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Herbert E Klei

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Jay A Bertrand

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John S Sack

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Kevin F Kish

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Lata Jayaraman

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Marina Fasolini

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Pamela Rosettani

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P2860

Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status

Methylation at arginine 17 of histone H3 is linked to gene activation

Crystal structure of the conserved core of protein arginine methyltransferase PRMT3

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

The structure and oligomerization of the yeast arginine methyltransferase, Hmt1

Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase

Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains

Coot: model-building tools for molecular graphics

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331-9

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686684

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10.1042/BJ20102161

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2

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436

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2011-06-01T00:00:00Z

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21410432

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