Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility
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Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malariaStructural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active siteIdentification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.New targets in the search for preventive and therapeutic agents for botulism.Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening
P2860
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P2860
Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility
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2011 nî lūn-bûn
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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2011 թվականի մայիսին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Structural Characterization of ...... ng from 60/70 Loop Flexibility
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Aaron A Thompson
Alan T Johnson
April Thai
Guan-Sheng Jiao
Gye Won Han
Lynne Cregar-Hernandez
Raymond C Stevens
Sean O'Malley
Seongjin Kim
Stephen A Margosiak
P2860
P304
P356
10.1021/BI2001483
P407
P577
2011-05-17T00:00:00Z