Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity - Wikidata - awgldk - TriplyDB

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

http://www.wikidata.org/entity/Q27667602

about

Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions Structure of the 34 kDa F-actin-bundling protein ABP34 from Dictyostelium discoideum Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Selective targeting of the stress chaperome as a therapeutic strategy Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7 HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Kinetics of protein-ligand unbinding via smoothed potential molecular dynamics simulations.Overproduction and biophysical characterization of human HSP70 proteins.Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Identification of potential tumor differentiation factor (TDF) receptor from steroid-responsive and steroid-resistant breast cancer cells.The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate: a novel inhibitor of 78 kDa glucose-regulated protein.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.CotH3 mediates fungal invasion of host cells during mucormycosis.Site-specific activation of AKT protects cells from death induced by glucose deprivation.Hsp70 protein complexes as drug targets.Effect of modulation of unfolded protein response pathway on dengue virus infection.Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment Chemical Proteomic Approaches Targeting Cancer Stem Cells: A Review of Current Literature.Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling.Synthesis of novel palladium(II) complexes with oxalic acid diamide derivatives and their interaction with nucleosides and proteins. Structural, solution, and computational study.AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.Disrupted hydrogen bond network and impaired ATPase activity in an Hsc70 cysteine mutant.Nuclear ERK5 inhibits progression of leukemic monocytes to macrophages by regulating the transcription factor PU.1 and heat shock protein HSP70.Structure prediction, expression, and antigenicity of c-terminal of GRP78.Repurposing drugs to target the malaria parasite unfolding protein response.Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling

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P2860

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity

http://www.wikidata.org/entity/Q27667602

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年论文

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name

Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Journal of Medicinal Chemistry

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Adenosine-derived inhibitors o ...... ights into isoform selectivity

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Alba T Macias

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Alexandra Clay

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Allan E Surgenor

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Andrew J Massey

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Christopher J Graham

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Douglas S Williamson

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Geraint L Francis

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James B Murray

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Jenifer Borgognoni

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Lindsey Terry

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4034-41

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scholarly article

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1870882

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10.1021/JM101625X

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12

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54

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21526763

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