Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity
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Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cellsBiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functionsStructure of the 34 kDa F-actin-bundling protein ABP34 from Dictyostelium discoideumExploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Selective targeting of the stress chaperome as a therapeutic strategyClose and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiPHsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription CompartmentsProteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Kinetics of protein-ligand unbinding via smoothed potential molecular dynamics simulations.Overproduction and biophysical characterization of human HSP70 proteins.Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Identification of potential tumor differentiation factor (TDF) receptor from steroid-responsive and steroid-resistant breast cancer cells.The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisPotassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate: a novel inhibitor of 78 kDa glucose-regulated protein.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.CotH3 mediates fungal invasion of host cells during mucormycosis.Site-specific activation of AKT protects cells from death induced by glucose deprivation.Hsp70 protein complexes as drug targets.Effect of modulation of unfolded protein response pathway on dengue virus infection.Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma TreatmentChemical Proteomic Approaches Targeting Cancer Stem Cells: A Review of Current Literature.Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulationDietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling.Synthesis of novel palladium(II) complexes with oxalic acid diamide derivatives and their interaction with nucleosides and proteins. Structural, solution, and computational study.AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.Disrupted hydrogen bond network and impaired ATPase activity in an Hsc70 cysteine mutant.Nuclear ERK5 inhibits progression of leukemic monocytes to macrophages by regulating the transcription factor PU.1 and heat shock protein HSP70.Structure prediction, expression, and antigenicity of c-terminal of GRP78.Repurposing drugs to target the malaria parasite unfolding protein response.Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling
P2860
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P2860
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@ast
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@en
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@nl
type
label
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@ast
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@en
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@nl
prefLabel
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@ast
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@en
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@nl
P2093
P3181
P356
P1476
Adenosine-derived inhibitors o ...... ights into isoform selectivity
@en
P2093
Alba T Macias
Alexandra Clay
Allan E Surgenor
Andrew J Massey
Christopher J Graham
Douglas S Williamson
Geraint L Francis
James B Murray
Jenifer Borgognoni
Lindsey Terry
P304
P3181
P356
10.1021/JM101625X
P407
P577
2011-06-23T00:00:00Z