Chemogenetic analysis of human protein methyltransferases - Wikidata - awgldk - TriplyDB

Chemogenetic analysis of human protein methyltransferases

Chemogenetic analysis of human protein methyltransferases

http://www.wikidata.org/entity/Q27667805

about

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2 Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Structural biology and chemistry of protein arginine methyltransferases Current chemical biology approaches to interrogate protein methyltransferases Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle Protein methylation at the surface and buried deep: thinking outside the histone box Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening Diverse involvement of EZH2 in cancer epigenetics Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1 Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1 Chemical Proteomic Profiling of Human Methyltransferases Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach Assay development for histone methyltransferases.ChromoHub: a data hub for navigators of chromatin-mediated signalling Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Fluorescence-based methods for screening writers and readers of histone methyl marks.A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer Recent progress in the discovery of small-molecule inhibitors of the HMT EZH2 for the treatment of cancer.The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.Selective inhibitors of protein methyltransferases Targeting histone methyltransferase EZH2 as cancer treatment.Chemical biology of protein arginine modifications in epigenetic regulation Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.Histone H3 lysine 4 methylation marks postreplicative human cytomegalovirus chromatin.Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation.Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.Protein Arginine Methylation and Citrullination in Epigenetic Regulation Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.

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Chemogenetic analysis of human protein methyltransferases

http://www.wikidata.org/entity/Q27667805

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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type

label

Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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Chemogenetic analysis of human protein methyltransferases

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J.1747-0285.2011.01135.X

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Chemical Biology and Drug Design

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Chemogenetic analysis of human protein methyltransferases

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Christina R Majer

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Christopher J Sneeringer

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Danielle Johnston

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L Fred Jerva

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Lei Jin

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Margaret Porter Scott

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Robert A Copeland

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Victoria M Richon

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P2860

FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues

Identification of protein N-terminal methyltransferases in yeast and humans

Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

The protein kinase complement of the human genome

The SET-domain protein superfamily: protein lysine methyltransferases

Processing of X-ray diffraction data collected in oscillation mode

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

Structural Biology of Human H3K9 Methyltransferases

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Coot: model-building tools for molecular graphics

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199-210

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686496

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10.1111/J.1747-0285.2011.01135.X

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2

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Keith O Elliston

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2011-06-16T00:00:00Z

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51119358

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