Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design
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Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based DesignCrystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding siteDiscovery of an allosteric mechanism for the regulation of HCV NS3 protein functionInterrogating HIV integrase for compounds that bind- a SAMPL challengeCrystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding PocketParallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding InhibitorExhaustive docking and solvated interaction energy scoring: lessons learned from the SAMPL4 challenge.Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.SAMPL4 & DOCK3.7: lessons for automated docking procedures.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014)."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.Support Vector Machine (SVM) Models for Predicting Inhibitors of the 3' Processing Step of HIV-1 Integrase.Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challengeComputational models on quantitative prediction of bioactivity of HIV-1 integrase 3' processing inhibitors.Virtual screening of the SAMPL4 blinded HIV integrase inhibitors dataset.Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4.
P2860
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P2860
Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Structural basis for a new mec ...... ing and structure-based design
@ast
Structural basis for a new mec ...... ing and structure-based design
@en
Structural basis for a new mec ...... ing and structure-based design
@nl
type
label
Structural basis for a new mec ...... ing and structure-based design
@ast
Structural basis for a new mec ...... ing and structure-based design
@en
Structural basis for a new mec ...... ing and structure-based design
@nl
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Structural basis for a new mec ...... ing and structure-based design
@ast
Structural basis for a new mec ...... ing and structure-based design
@en
Structural basis for a new mec ...... ing and structure-based design
@nl
P2093
P50
P356
P1476
Structural basis for a new mec ...... ing and structure-based design
@en
P2093
Craig L Francis
David I Rhodes
Del Lucent
Dharshini Jeevarajah
Eric D Jones
Jessica A Smith
John H Ryan
John J Deadman
Jonathan A V Coates
P304
P356
10.3851/IMP1716
P577
2011-03-07T00:00:00Z