Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors
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Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific PeptidasesHalogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53A Protein Data Bank survey reveals shortening of intermolecular hydrogen bonds in ligand-protein complexes when a halogenated ligand is an H-bond donorMolecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition.Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Halogen bonding for rational drug design and new drug discovery.Halogen bonding in medicinal chemistry: from observation to prediction.Relationships between hydrogen bonds and halogen bonds in biological systems.A quantum mechanics-based halogen bonding scoring function for protein-ligand interactions.Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen AtomsComparison of halogen bonding networks with Ru(ii) complexes and analysis of the influence of the XB interactions on their reactivity.A systematic analysis of atomic protein-ligand interactions in the PDB.Using halogen bonds to address the protein backbone: a systematic evaluation.Discovering protein-ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets.Looking Back, Looking Forward at Halogen Bonding in Drug Discovery.A knowledge-based halogen bonding scoring function for predicting protein-ligand interactions.Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor-Ligand InteractionsApplication of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design
P2860
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P2860
Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@ast
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@en
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@nl
type
label
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@ast
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@en
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@nl
prefLabel
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@ast
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@en
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@nl
P2093
P356
P1476
Utilization of halogen bond in ...... erase type 5 (PDE5) inhibitors
@en
P2093
Guanghui Tian
Hualiang Jiang
Jingshan Shen
Kaixian Chen
Shudong Wang
TianTian Chen
Weiliang Zhu
P304
P356
10.1021/JM200644R
P407
P577
2011-08-11T00:00:00Z