Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents
about
Design of activated serine–containing catalytic triads with atomic-level accuracyEnzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis.Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.Highly diverse protein library based on the ubiquitous (β/α)₈ enzyme fold yields well-structured proteins through in vitro folding selection.Sulfhydryl-specific PEGylation of phosphotriesterase cysteine mutants for organophosphate detoxification.Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP).Probiotic Lactobacillus rhamnosus Reduces Organophosphate Pesticide Absorption and Toxicity to Drosophila melanogaster.Drug development for the management of organophosphorus poisoning.Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Exploring stereochemical specificity of phosphotriesterase by MM-PBSA and MM-GBSA calculation and steered molecular dynamics simulation.In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.An evolutionary biochemist's perspective on promiscuity.Impact of phenylalanines outside the dimer interface on phosphotriesterase stability and function.Biocatalytic Stimuli-Responsive Asymmetric Triblock Terpolymer Membranes for Localized Permeability Gating.The effect of conformational variability of phosphotriesterase upon N-acyl-L-homoserine lactone and paraoxon binding: insights from molecular dynamics studies.Quantum dot display enhances activity of a phosphotriesterase trimer.Stereoselectivity of phosphotriesterase with paraoxon derivatives: a computational study.Microbiota-Mediated Modulation of Organophosphate Insecticide Toxicity by Species-Dependent Interactions with Lactobacilli in a Drosophila melanogaster Insect Model.Enzymatic detoxification of organophosphorus pesticides and related toxicantsInnovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents
P2860
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P2860
Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents
description
2012 nî lūn-bûn
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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@ast
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@en
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@nl
type
label
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@ast
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@en
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@nl
prefLabel
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@ast
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@en
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@nl
P2093
P2860
P356
P1433
P1476
Enzymes for the Homeland Defen ...... f Organophosphate Nerve Agents
@en
P2093
Andrew N Bigley
David P Barondeau
Nicholas Fox
Ping-Chuan Tsai
Steven P Harvey
P2860
P304
P356
10.1021/BI300811T
P407
P577
2012-08-14T00:00:00Z