Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
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Disease modifying therapies for Alzheimer's disease targeting Aβ oligomers: implications for therapeutic mechanismsAn Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomersAmyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels.Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau.A generic method for design of oligomer-specific antibodies.Synthesis and systematic evaluation of dark resonance energy transfer (DRET)-based library and its application in cell imaging.Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity.Chemical Fluorescent Probe for Detection of Aβ Oligomers.High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide.Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoidDesign and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid PolypeptideStructural insights into Aβ42 oligomers using site-directed spin labelingFabrication of an antibody-aptamer sandwich assay for electrochemical evaluation of levels of β-amyloid oligomers.Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease.Structural, morphological, and functional diversity of amyloid oligomers.Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease.Detection of Aβ Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease.Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer's Disease Immunotherapy.Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes.Peptide backbone modification in the bend region of amyloid-β inhibits fibrillogenesis but not oligomer formation5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro.Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide.Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations.Binding affinity prediction of nanobody-protein complexes by scoring of molecular dynamics trajectories.Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.Engineering of a peptide probe for β-amyloid aggregates.An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids.Inhibition of Protein Aggregation by Several Antioxidants.
P2860
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P2860
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@ast
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@en
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@nl
type
label
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@ast
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@en
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@nl
prefLabel
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@ast
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@en
Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment
@nl
P2093
P2860
P50
P3181
P356
P1476
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment
@en
P2093
Christian Mawrin
Christoph Parthier
Cordelia Schiene-Fischer
Jessica Wacker
Jochen Balbach
Karin Wieligmann
Karthikeyan Annamalai
Katrin Meinhardt
Klaus G Reymann
Magdalena Bereza
P2860
P304
12503-12508
P3181
P356
10.1073/PNAS.1206433109
P407
P577
2012-07-18T00:00:00Z