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Tapping natural reservoirs of homing endonucleases for targeted gene modification

Tapping natural reservoirs of homing endonucleases for targeted gene modification

http://www.wikidata.org/entity/Q27670974

about

Optimising homing endonuclease gene drive performance in a semi-refractory species: the Drosophila melanogaster experience Targeted gene disruption to cure HIV Homing endonucleases: DNA scissors on a mission Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space Visualizing phosphodiester-bond hydrolysis by an endonuclease Protein sequence alignment analysis by local covariation: coevolution statistics detect benchmark alignment errors.LAHEDES: the LAGLIDADG homing endonuclease database and engineering server megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs Massively parallel determination and modeling of endonuclease substrate specificity The developmental transcriptome of the mosquito Aedes aegypti, an invasive species and major arbovirus vector The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution Homing endonucleases: from genetic anomalies to programmable genomic clippers A tetO Toolkit To Alter Expression of Genes in Saccharomyces cerevisiae.Generation and Inheritance of Targeted Mutations in Potato (Solanum tuberosum L.) Using the CRISPR/Cas System Using Group II Introns for Attenuating the In Vitro and In Vivo Expression of a Homing Endonuclease Monomeric site-specific nucleases for genome editing.Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.Accelerated genome engineering through multiplexing.The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease.Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference Rapid assembly of customized TALENs into multiple delivery systems.Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.Reprogramming homing endonuclease specificity through computational design and directed evolution.Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering.The Development of TALE Nucleases for Biotechnology.Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization.Molecular scissors for in situ cellular repair.Targeted gene therapies: tools, applications, optimization Recent advances in targeted genome engineering in mammalian systems.Salient Features of Endonuclease Platforms for Therapeutic Genome Editing Gene editing for cell engineering: trends and applications.Genome Editing Techniques and Their Therapeutic Applications.The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.Germline excision of transgenes in Aedes aegypti by homing endonucleases.Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses.Engineering of customized meganucleases via in vitro compartmentalization and in cellulo optimization.

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P2860

Tapping natural reservoirs of homing endonucleases for targeted gene modification

http://www.wikidata.org/entity/Q27670974

description

2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

@zh-tw

2011年论文

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name

Tapping natural reservoirs of homing endonucleases for targeted gene modification

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

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type

label

Tapping natural reservoirs of homing endonucleases for targeted gene modification

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

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prefLabel

Tapping natural reservoirs of homing endonucleases for targeted gene modification

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

@en

Tapping natural reservoirs of homing endonucleases for targeted gene modification

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PNAS.1107719108

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Proceedings of the National Academy of Sciences of the United States of America

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Tapping natural reservoirs of homing endonucleases for targeted gene modification

@en

P2093

Abigail R Lambert

http://www.w3.org/2001/XMLSchema#string

Amanda Nga-Sze Mak

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Andrew M Scharenberg

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Barry L Stoddard

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David R Edgell

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Kyle Jacoby

http://www.w3.org/2001/XMLSchema#string

Russell J Dickson

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Ryo Takeuchi

http://www.w3.org/2001/XMLSchema#string

P2860

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

Targeting DNA double-strand breaks with TAL effector nucleases

Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds

Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

A highly sensitive selection method for directed evolution of homing endonucleases.

Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI

The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity

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13077-13082

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scholarly article

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4621012

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10.1073/PNAS.1107719108

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32

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108

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Gregory B. Gloor

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2011-07-22T00:00:00Z

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51517287

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21784983

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3156218

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