about
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafishTunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionDual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activityZinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell developmentZinc-binding cysteines: diverse functions and structural motifs.Zinc in Infection and Inflammation.A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Modifying caspase-3 activity by altering allosteric networks.Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells.The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3.Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved PharmacokineticsSmall Molecule Active Site Directed Tools for Studying Human CaspasesDerivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.Caspase substrates and inhibitorsCaspase-6 as a novel early target in the treatment of Alzheimer's disease.The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.The inhibition of voltage-gated H+ channel (HVCN1) induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis.Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications.Theoretical study on the allosteric regulation of an oligomeric protease from Pyrococcus horikoshii by Cl- Ion.Inhibitory zinc sites in enzymes.Zinc in Wound Healing Modulation.Interdependence of free zinc changes and protein complex assembly - insights into zinc signal regulation.Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8.Modifications to a common phosphorylation network provide individualized control in caspases.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Zinc-mediated Allosteric Inhibition of Caspase-6
@ast
Zinc-mediated Allosteric Inhibition of Caspase-6
@en
Zinc-mediated Allosteric Inhibition of Caspase-6
@nl
type
label
Zinc-mediated Allosteric Inhibition of Caspase-6
@ast
Zinc-mediated Allosteric Inhibition of Caspase-6
@en
Zinc-mediated Allosteric Inhibition of Caspase-6
@nl
prefLabel
Zinc-mediated Allosteric Inhibition of Caspase-6
@ast
Zinc-mediated Allosteric Inhibition of Caspase-6
@en
Zinc-mediated Allosteric Inhibition of Caspase-6
@nl
P2860
P356
P1476
Zinc-mediated Allosteric Inhibition of Caspase-6
@en
P2093
Elih M Velázquez-Delgado
Jeanne A Hardy
P2860
P304
P356
10.1074/JBC.M112.397752
P407
P577
2012-10-19T00:00:00Z