Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
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Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesisRegulation of antiviral innate immune signaling by stress-induced RNA granulesDefining the functional determinants for RNA surveillance by RIG-IStructural basis for the prion-like MAVS filaments in antiviral innate immunityCrystal and solution structure of the human RIG-I SF2 domainSelective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.A structure-based model of RIG-I activationEfficient solid-phase synthesis of pppRNA by using product-specific labeling.Structural biology of innate immunity.Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5Activation of PKR by short stem-loop RNAs containing single-stranded arms.When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing.Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors.Parts, assembly and operation of the RIG-I family of motors.Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA.Establishing the role of ATP for the function of the RIG-I innate immune sensorDrosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain.Structural and biochemical studies of RIG-I antiviral signaling.Regulation of RIG-I Activation by K63-Linked Polyubiquitination.Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis.A minimal RNA ligand for potent RIG-I activation in living mice.Viruses Seen by Our Cells: The Role of Viral RNA Sensors.Energetics of Preferential Binding of Retinoic Acid-Inducible Gene-I to Double-Stranded Viral RNAs with 5' Tri-/Diphosphate over 5' Monophosphate.
P2860
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P2860
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
description
2012 nî lūn-bûn
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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@ast
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@en
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@nl
type
label
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@ast
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@en
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@nl
prefLabel
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@ast
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@en
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@nl
P2093
P2860
P3181
P1433
P1476
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I
@en
P2093
Adriana Vela
Andrew Kohlway
Anna Marie Pyle
P2860
P304
P3181
P356
10.1016/J.STR.2012.08.029
P50
P577
2012-11-07T00:00:00Z