Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I - Wikidata - awgldk - TriplyDB

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

http://www.wikidata.org/entity/Q27673741

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Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis Regulation of antiviral innate immune signaling by stress-induced RNA granules Defining the functional determinants for RNA surveillance by RIG-I Structural basis for the prion-like MAVS filaments in antiviral innate immunity Crystal and solution structure of the human RIG-I SF2 domain Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.A structure-based model of RIG-I activation Efficient solid-phase synthesis of pppRNA by using product-specific labeling.Structural biology of innate immunity.Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5 Activation of PKR by short stem-loop RNAs containing single-stranded arms.When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing.Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors.Parts, assembly and operation of the RIG-I family of motors.Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA.Establishing the role of ATP for the function of the RIG-I innate immune sensor Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain.Structural and biochemical studies of RIG-I antiviral signaling.Regulation of RIG-I Activation by K63-Linked Polyubiquitination.Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis.A minimal RNA ligand for potent RIG-I activation in living mice.Viruses Seen by Our Cells: The Role of Viral RNA Sensors.Energetics of Preferential Binding of Retinoic Acid-Inducible Gene-I to Double-Stranded Viral RNAs with 5' Tri-/Diphosphate over 5' Monophosphate.

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Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

http://www.wikidata.org/entity/Q27673741

description

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

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Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

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Anna Marie Pyle

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P2860

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

PHENIX: a comprehensive Python-based system for macromolecular structure solution

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

Structural Insights into RNA Recognition by RIG-I

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

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