Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
about
Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicityHuman immunoglobulin E flexes between acutely bent and extended conformations.Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells.Novel targeted therapies for eosinophil-associated diseases and allergyThe Potential of Anti-IgE in Food Allergy Therapy."Auto-anti-IgE": naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation.Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies.Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.Facilitated Dissociation of a Nucleoid Protein from the Bacterial Chromosome.Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseasesIgE-Related Chronic Diseases and Anti-IgE-Based Treatments.HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.An overview of the effects of anti-IgE therapies.The future of biologics: applications for food allergy.Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.Looking forward to new targeted treatments for chronic spontaneous urticaria.From IgE to Omalizumab.Allergens displayed on virus-like particles are highly immunogenic but fail to activate human mast cells.SplitCore Technology Allows Efficient Production of Virus-Like Particles Presenting a Receptor-Contacting Epitope of Human IgE.Sensing and responding to allergic response cytokines through a genetically encoded circuit.Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.Omalizumab is effective in treating severe asthma in patients with severe cardiovascular complications and its effects on sCD200, d-dimer, CXCL8, 25-hydroxyvitamin D and IL-1β levels.IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils.
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P2860
Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@ast
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@en
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@nl
type
label
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@ast
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@en
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@nl
prefLabel
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@ast
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@en
Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@nl
P2093
P2860
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P356
P1433
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Accelerated disassembly of IgE ...... ptive macromolecular inhibitor
@en
P2093
Beomkyu Kim
Heino Prinz
Monique Vogel
Svetlana S Tarchevskaya
Theodore S Jardetzky
P2860
P2888
P304
P3181
P356
10.1038/NATURE11546
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P50
P577
2012-10-28T00:00:00Z
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P6179
1015817893