Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

Item
http://www.wikidata.org/entity/Q27674947
The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosisInhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and HydrazidesTarget-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.Mycobacterium tuberculosis metabolismFragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.Genetic Approaches to Facilitate Antibacterial Drug Development.Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis.In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA).Recent advances in the Overman rearrangement: synthesis of natural products and valuable compounds.Use of differential scanning fluorimetry to optimize the purification and crystallization of PLP-dependent enzymes.Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal.Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogues as Mechanism-Based Inhibitors of BioA, a Pyridoxal Phosphate-Dependent Enzyme.Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.Targeting protein biotinylation enhances tuberculosis chemotherapy.Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening.
P2860

Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

Item
http://www.wikidata.org/entity/Q27674947
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@ast
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@en
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@nl
type
label
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@ast
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@en
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@nl
prefLabel
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@ast
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@en
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Mechanism-based Inactivation b ...... s in Mycobaterium tuberculosis
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932