Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations - Wikidata - awgldk - TriplyDB

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

http://www.wikidata.org/entity/Q27674953

about

Structural studies of CNG repeats Utilizing the GAAA Tetraloop/Receptor To Facilitate Crystal Packing and Determination of the Structure of a CUG RNA Helix A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.Stacking in RNA: NMR of Four Tetramers Benchmark Molecular Dynamics Trinucleotide repeats: a structural perspective Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1 Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.Methods to enable the design of bioactive small molecules targeting RNA.Oligonucleotide-based strategies to combat polyglutamine diseases.MBNL proteins and their target RNAs, interaction and splicing regulation.Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.Features of modularly assembled compounds that impart bioactivity against an RNA target.Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs)RNA Structures as Mediators of Neurological Diseases and as Drug Targets.On the Applicability of Elastic Network Models for the Study of RNA CUG Trinucleotide Repeat Overexpansion.Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).Small-molecule-mediated cleavage of RNA in living cells.A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.An innate twist between Crick's wobble and Watson-Crick base pairs.Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.Structures of RNA repeats associated with neurological diseases.Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

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P2860

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

http://www.wikidata.org/entity/Q27674953

description

2011 nî lūn-bûn

@nan

2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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Myotonic Dystrophy Type 1 RNA ...... UU Internal Loop Conformations

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Myotonic Dystrophy Type 1 RNA ...... UU Internal Loop Conformations

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Myotonic dystrophy type 1 RNA ...... UU internal loop conformations

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Amit Kumar

http://www.w3.org/2001/XMLSchema#string

HaJeung Park

http://www.w3.org/2001/XMLSchema#string

Kendall W Nettles

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Matthew D Disney

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Min Guo

http://www.w3.org/2001/XMLSchema#string

Raman Parkesh

http://www.w3.org/2001/XMLSchema#string

P2860

A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics

Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.

Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site

A General Strategy to Solve the Phase Problem in RNA Crystallography

Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites

The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates

Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy

Crystal structure of the eukaryotic ribosome

NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.

The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG)

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9928-9935

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scholarly article

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5072482

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10.1021/BI2013068

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45

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50

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2011-10-20T00:00:00Z

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21988728

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crystal structure

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3218087

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