Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth - Wikidata - awgldk - TriplyDB

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

http://www.wikidata.org/entity/Q27675143

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Novel drugs that target the metabolic reprogramming in renal cell cancer Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Mitochondria in Cancer Energy Metabolism: Culprits or Bystanders?Energy metabolism in neurodevelopment and medulloblastoma 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling Serine, glycine and one-carbon units: cancer metabolism in full circle Disruptive chemicals, senescence and immortality Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation Heterogeneity of glycolysis in cancers and therapeutic opportunities.A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1.Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.A joint analysis of metabolomics and genetics of breast cancer.Techniques to monitor glycolysis.Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.Expression of PGAM1 in renal clear cell carcinoma and its clinical significance.Identification of gene-drug interactions that impact patient survival in TCGA.BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas.PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells.HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations Cancer metabolism: fatty acid oxidation in the limelight.Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.Altered glutamine metabolism and therapeutic opportunities for lung cancer.Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development.Molecular dynamics simulation reveals how phosphorylation of tyrosine 26 of phosphoglycerate mutase 1 upregulates glycolysis and promotes tumor growth.Post-translational modifications and the Warburg effect.Stress eating and tuning out: cancer cells re-wire metabolism to counter stress.The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications.Targeting glucose metabolism in patients with cancer.The pentose phosphate pathway and cancer.

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

http://www.wikidata.org/entity/Q27675143

description

2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Benjamin H Lee

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Changliang Shan

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Chi-Hao Luan

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Chuan He

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Dong M Shin

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Fadlo R Khuri

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Gary LeRoy

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Georgia Z Chen

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Hanna J Khoury

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Hee-Bum Kang

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P2860

Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism

Regulation of cancer cell metabolism

Bidirectional transport of amino acids regulates mTOR and autophagy

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

Akt stimulates aerobic glycolysis in cancer cells

Tumor cell metabolism: cancer's Achilles' heel

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery.

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.

Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma.

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Taofeek K. Owonikoko

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