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Antibacterial drug leads targeting isoprenoid biosynthesis

Antibacterial drug leads targeting isoprenoid biosynthesis

http://www.wikidata.org/entity/Q27675524

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Exploring the role of receptor flexibility in structure-based drug discovery Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase Resistance-resistant antibiotics Computational methods in drug discovery.Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis.Deciphering the metabolism of undecaprenyl-phosphate: the bacterial cell-wall unit carrier at the membrane frontier Expedient Synthesis of SMAMPs via Click Chemistry.Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.Machine-learning techniques applied to antibacterial drug discovery Species differences in alternative substrate utilization by the antibacterial target undecaprenyl pyrophosphate synthase.A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.Tunable protein degradation in bacteria.Tuning the production of variable length, fluorescent polyisoprenoids using surfactant-controlled enzymatic synthesis.Antibacterial drug leads: DNA and enzyme multitargeting In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection.Antiinfectives targeting enzymes and the proton motive force.Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands.Farnesyl diphosphate synthase inhibitors from in silico screening.Molecular simulations of aromatase reveal new insights into the mechanism of ligand binding.Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics.Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.Enhanced molecular dynamics sampling of drug target conformations.Imidazoline scaffold in medicinal chemistry: a patent review (2012-2015).cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases.Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase.Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.Antibacterial drugs: New antibiotics on the horizon?Determination of residues responsible for substrate and product specificity of Solanum habrochaites short-chain cis-prenyltransferases.Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions.Gene Network Analysis of Metallo Beta Lactamase Family Proteins Indicates the Role of Gene Partners in Antibiotic Resistance and Reveals Important Drug Targets.Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes

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P2860

Antibacterial drug leads targeting isoprenoid biosynthesis

http://www.wikidata.org/entity/Q27675524

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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Antibacterial drug leads targeting isoprenoid biosynthesis

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PNAS.1219899110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Antibacterial drug leads targeting isoprenoid biosynthesis

@en

P2093

Anna Sankovsky

http://www.w3.org/2001/XMLSchema#string

César Augusto F de Oliveira

http://www.w3.org/2001/XMLSchema#string

Eric Oldfield

http://www.w3.org/2001/XMLSchema#string

Joshua Olson

http://www.w3.org/2001/XMLSchema#string

Kai Li

http://www.w3.org/2001/XMLSchema#string

Katie J Molohon

http://www.w3.org/2001/XMLSchema#string

Ke Wang

http://www.w3.org/2001/XMLSchema#string

Mary E Hensler

http://www.w3.org/2001/XMLSchema#string

Steffen Lindert

http://www.w3.org/2001/XMLSchema#string

Wei Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

Structure-Based Inhibitors Exhibit Differential Activities againstHelicobacter pyloriandEscherichia coliUndecaprenyl Pyrophosphate Synthases

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene.

Discovery and initial development of a novel class of antibacterials: inhibitors of Staphylococcus aureus transcription/translation.

Optimization of high throughput virtual screening by combining shape-matching and docking methods.

De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.

Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.

Scoring residue conservation.

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.

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123-8

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scholarly article

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10.1073/PNAS.1219899110

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1

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110

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Douglas A Mitchell

J. Andrew McCammon

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2013-01-02T00:00:00Z

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23248302

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3538244

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