Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase - Wikidata - awgldk - TriplyDB

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

http://www.wikidata.org/entity/Q27675581

about

CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Tuberculosis drug discovery in the post-post-genomic era Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange A new drug for an old bug Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data.The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.Discovery of Mycobacterium tuberculosis α-1,4-glucan branching enzyme (GlgB) inhibitors by structure- and ligand-based virtual screening.The tuberculosis drug discovery and development pipeline and emerging drug targets.Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3 Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Tuberculosis drug discovery and emerging targets.Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1.Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.The Mycobacterium tuberculosis H37Ra gene MRA_1916 causes growth defects upon down-regulation.Sun sets on protein initiative, casting shadow over drug discovery.Novel Pyrimidines as Antitubercular Agents.Anion-π interactions in complexes of proteins and halogen-containing amino acids.Two isocitrate dehydrogenases from a plant pathogen Xanthomonas campestris pv. campestris 8004. Bioinformatic analysis, enzymatic characterization, and implication in virulence.TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.Experimental investigation of anion-π interactions--applications and biochemical relevance.RosettaLigandEnsemble: A Small-Molecule Ensemble-Driven Docking Approach.Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.On the non-classical contribution in lone-pair–π interaction: IQA perspective

P2860

Q24312732-2F322FBA-B704-4464-8398-84DE68514BDF Q26795478-844F6B98-62F5-4622-B690-28B988F93DE0 Q26864729-8408D8B5-69B3-4454-BE3B-4A7F5912D449 Q27728469-7DAA9525-862A-43BC-BB1B-8EAFC6DE67D8 Q28710106-F453792B-027B-43FC-972E-67FADA967058 Q30432374-B82F160A-F87D-408E-9E5A-1E2C3B2F4955 Q30672146-71499ECB-BEDF-48D1-9263-E9F044F89CEC Q34297745-A6F669DE-FEA4-489D-88B8-1B08CD9BFE2F Q34567153-47CBC62D-1070-4091-9B43-FF01F6611FCF Q34801781-77C3F47F-EE04-428A-95A9-2669545AAAF4 Q35664209-47AEE457-8251-4AC0-AA62-DA07399C4EC4 Q37203793-CDF83808-7C66-4A07-83E7-909AEB255FD0 Q37497737-9AB24FF6-5741-4D01-A5B9-F8987D991683 Q38219605-AF72585F-6053-48C7-AD41-5BE39BDCB855 Q40106207-CB51A053-CA5D-47C5-B75E-2EC28B73E609 Q40306037-45A2DCF2-D07B-430C-9AAA-20F4A5E1499B Q41990490-03BED5E0-4BA8-4B36-A4B7-2CA9E01C7803 Q44293102-32D4B921-AE24-4262-92ED-3FBA4EBB900A Q50134166-22861740-B0C9-4AE8-8ECC-BD14E090C78F Q51497789-2160C23B-1DC7-4791-AA62-5BE753B7B90F Q51711094-83C6B7B2-076E-4BD4-9FD0-9847D8A9B785 Q52673950-F0AC0BEF-88CD-4EC7-8F31-6419AD0E0872 Q53239114-CB7C0EB7-20C2-4135-85A0-053A07DA8699 Q55012557-86228113-9781-4B02-8055-189648B2BBF2 Q55091455-25F68DD0-8F9A-46FF-A8EF-B7D9CE834598 Q57744759-B5C2BE3D-7A46-4935-8967-D669370D19B7

P2860

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

http://www.wikidata.org/entity/Q27675581

description

2012 nî lūn-bûn

@nan

2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@ast

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@en

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@nl

type

label

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@ast

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@en

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@nl

prefLabel

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@ast

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@en

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@nl

P1433

Q27675581-0E21608B-8C24-408F-B7C6-FBECB2AB8685

P1476

Q27675581-5CEB5F60-1BED-44ED-ADB3-37B74D2FD587

P2093

Q27675581-0318FF9C-2A14-48C8-9E9F-2EFB322E5293

Q27675581-25B03A79-0477-499E-8130-1A1A17289A1B

Q27675581-316D3DCE-8076-494A-A6CE-D3639EC2445D

Q27675581-3FD4716A-758C-4907-B23E-99B67F0129BC

Q27675581-705FB857-B926-45A2-8859-3D8A28788525

Q27675581-A8959B12-9699-480D-A084-E6766BE6DF55

Q27675581-BF240EBF-39C0-4B5F-9D80-3F4F6847E85D

Q27675581-C086E1A2-F7F5-4BAF-8AF6-71751717ABEA

Q27675581-CB90EF25-5A8C-4524-8729-8EE89CDBF4E6

Q27675581-D647EAF4-70C9-47CF-A1F8-CC773CF64932

P2860

Q27675581-007E87D0-91D0-43DF-B6C4-37634981BE13

Q27675581-0110B6BB-F75B-4EB8-93FF-373C81EA602D

Q27675581-0C2C7146-ECF7-4BF5-86CF-AC6EEAC58085

Q27675581-0D0E7CC1-33B8-4FEA-B41A-06A38790F6E6

Q27675581-1ACFDC5C-F450-49EA-A4AA-5572FEDAC213

Q27675581-1C43A4BB-90C5-48D2-B048-94ACB15BA603

Q27675581-1E97694D-7C21-4932-B824-16787466D906

Q27675581-271F2ED1-F13A-4E03-AF2B-525F6D8BA4FF

Q27675581-35ECC174-1042-4B2F-A2E0-6C18342A21BC

Q27675581-377C9DA4-1EBD-4364-A6D6-27A30FAA322B

P304

Q27675581-6AF63FD1-A6A1-43E1-A143-FD457A7F75AE

P31

Q27675581-B58E2EC8-8CB6-49D4-B293-00DBAB1B0E7E

P3181

Q27675581-8D19B897-FD1C-43B3-8163-FA977EA7DDD3

P356

Q27675581-80C20C64-F95B-46AD-B128-002C7A06DE32

P433

Q27675581-59F215A9-D9FA-4CF6-B46F-B4FB73152E38

P478

Q27675581-B8DA872B-7CAA-4E07-A7C7-8BC3254DFA03

P577

Q27675581-C6FBCD42-A71B-4ED2-A37F-9F1DD6F54D5D

P5875

Q27675581-70A43103-A6E8-4F4E-9B87-1A5A7A6045FC

P698

Q27675581-4CE8D1C4-D33E-4565-B86F-5099D29C0550

P921

Q27675581-00E1715B-E624-4537-990E-0FCD00F4AEFE

Q27675581-4C7D4746-AD4E-471E-8519-139E669E2D69

Q27675581-8FF15F47-5C77-4796-95FA-815988EA85C4

Q27675581-92FF840D-E358-4962-B1A0-17B32E14FCF6

P932

Q27675581-31289622-70F1-448C-B9E5-45AE4CCA257A

P3181

P356

J.CHEMBIOL.2012.09.018

P1433

Chemistry and Biology

P1476

Structure-Guided Discovery of ...... . tuberculosis Malate Synthase

@en

P2093

Inna V Krieger

http://www.w3.org/2001/XMLSchema#string

James C Sacchettini

http://www.w3.org/2001/XMLSchema#string

Joel S Freundlich

http://www.w3.org/2001/XMLSchema#string

Jose-Luis Lavandera

http://www.w3.org/2001/XMLSchema#string

Joshua L Owen

http://www.w3.org/2001/XMLSchema#string

Justin P Roberts

http://www.w3.org/2001/XMLSchema#string

Maria T Fraile

http://www.w3.org/2001/XMLSchema#string

Qingan Sun

http://www.w3.org/2001/XMLSchema#string

Sofia I Huss

http://www.w3.org/2001/XMLSchema#string

Thomas R Ioerger

http://www.w3.org/2001/XMLSchema#string

P2860

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

Biochemical differentiation of Mycobacterium tuberculosis grown in vivo and in vitro

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis

Structure of theEscherichia colimalate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 Å resolution

Structure of an archaeal alanine:glyoxylate aminotransferase

UCSF Chimera--a visualization system for exploratory research and analysis

REFMAC5 for the refinement of macromolecular crystal structures

PHENIX: building new software for automated crystallographic structure determination

P304

1556-67

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3324612

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/J.CHEMBIOL.2012.09.018

http://www.w3.org/2001/XMLSchema#string

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2012-12-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

233974743

http://www.w3.org/2001/XMLSchema#string

P698

23261599

http://www.w3.org/2001/XMLSchema#string

P921

Akafuba bulwadde

Mycobacterium tuberculosis

clinical chemistry

P932

3530165

http://www.w3.org/2001/XMLSchema#string