The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
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Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitorsThermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteasesReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)The water network in galectin-3 ligand binding site guides inhibitor designHuman galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutinationQuantitative proteomics reveal the anti-tumour mechanism of the carbohydrate recognition domain of Galectin-3 in Hepatocellular carcinoma.Protein crystallography and fragment-based drug design.Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins.Understanding the specificity of human Galectin-8C domain interactions with its glycan ligands based on molecular dynamics simulationsStructural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc.Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3CSphingolipid transfer proteins defined by the GLTP-fold.The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation.Initial recognition of a cellodextrin chain in the cellulose-binding tunnel may affect cellobiohydrolase directional specificity.Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker.Effect of subdomain interactions on methyl group dynamics in the hydrophobic core of villin headpiece protein.Galectin-3 inhibitors: a patent review (2008-present).Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose.Using crystallographic water properties for the analysis and prediction of lectin-carbohydrate complex structures.Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3.Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer.Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMRMolecular modeling of methyl-α-Neu5Ac analogues docked against cholera toxin--a molecular dynamics study.Galectin-3 alters the lateral mobility and clustering of β1-integrin receptors.Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin-3 Inhibitor.Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen-Deuterium Exchange.Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling.Protein-Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy.Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.Exploring the Structural Space of the Galectin-1-Ligand Interaction.Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.Chemical Shifts of the Carbohydrate Binding Domain of Galectin-3 from Magic Angle Spinning NMR and Hybrid Quantum Mechanics/Molecular Mechanics Calculations.Crystallization of a human galectin-3 variant with two ordered segments in the shortened N-terminal tail.
P2860
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P2860
The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@ast
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@en
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@nl
type
label
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@ast
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@en
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@nl
prefLabel
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@ast
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@en
The Carbohydrate-Binding Site ...... Structures and Water Dynamics
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
The carbohydrate-binding site ...... structures and water dynamics
@en
P2093
Carl Diehl
Johan Qvist
Kadhirvel Saraboji
Maria Håkansson
Mikael Akke
P2860
P304
P3181
P356
10.1021/BI201459P
P407
P577
2011-12-07T00:00:00Z