7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes - Wikidata - awgldk - TriplyDB

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

http://www.wikidata.org/entity/Q27675915

about

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode De Novo Fragment Design for Drug Discovery and Chemical Biology Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.Identification of type I and type II inhibitors of c-Yes kinase using in silico and experimental techniques.Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Insights from Pim1 structure for anti-cancer drug design.A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.Chemical and photochemical properties of chloroharmine derivatives in aqueous solutions.Using halogen bonds to address the protein backbone: a systematic evaluation.Synthesis of desaza analogues of annomontine and canthin-4-one alkaloids.

P2860

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P2860

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

http://www.wikidata.org/entity/Q27675915

description

2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012 թվականի հունվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Journal of Medicinal Chemistry

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7,8-Dichloro-1-oxo-β-carboline ...... ors with Unusual Binding Modes

@en

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Alex N Bullock

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Christelle Gasser

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Doriano Fabbro

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Franz Bracher

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Jörg Trappe

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Jürg Schwaller

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Laurent Brault

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P2860

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex

DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression

The protein kinase complement of the human genome

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

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403-13

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scholarly article

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3831413

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P356

10.1021/JM201286Z

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1

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55

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Panagis Filippakopoulos

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2012-01-12T00:00:00Z

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51848668

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22136433

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3257585

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