The Structure of the Tiam1 PDZ Domain/ Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics

The Structure of the Tiam1 PDZ Domain/ Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics

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http://www.wikidata.org/entity/Q27676266
Syndecans as Cell Surface Receptors in Cancer Biology. A Focus on their Interaction with PDZ Domain ProteinsPromotion of Enzyme Flexibility by Dephosphorylation and Coupling to the Catalytic Mechanism of a PhosphohexomutaseA molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complexCytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.Understanding the role of phosphorylation in the binding mechanism of a PDZ domain.Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.A Simple PB/LIE Free Energy Function Accurately Predicts the Peptide Binding Specificity of the Tiam1 PDZ DomainThe phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner.Phosphorylation of tight junction transmembrane proteins: Many sites, much to do.Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions.Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.Accurate PDZ/Peptide Binding Specificity with Additive and Polarizable Free Energy Simulations.Energy transport pathway in proteins: Insights from non-equilibrium molecular dynamics with elastic network model.Proteome-wide analysis of phospho-regulated PDZ domain interactions
P2860

The Structure of the Tiam1 PDZ Domain/ Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics

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http://www.wikidata.org/entity/Q27676266
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The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@ast
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@en
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
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label
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@ast
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@en
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@nl
prefLabel
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@ast
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@en
The Structure of the Tiam1 PDZ ...... hat Modulates Protein Dynamics
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
The structure of the Tiam1 PDZ ...... hat modulates protein dynamics
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932