Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

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http://www.wikidata.org/entity/Q27676380
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsFunction-specific virtual screening for GPCR ligands using a combined scoring methodAntiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug RepositioningRepurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitorsRepurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.An overview of molecular fingerprint similarity search in virtual screening.Characterization of parasite-specific indels and their proposed relevance for selective anthelminthic drug targeting.Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).Drug discovery and human African trypanosomiasis: a disease less neglected?cAMP signalling in trypanosomatids: role in pathogenesis and as a drug target.Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target.A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response.Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
P2860

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

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http://www.wikidata.org/entity/Q27676380
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2013 nî lūn-bûn
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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type
label
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
@en
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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prefLabel
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
@ast
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
@en
Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
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Discovery of Novel Trypanosoma ...... ded TbrPDEB1 Crystal Structure
@en
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932