Allosteric inhibition of hypoxia inducible factor-2 with small molecules
about
Targeting Protein-Protein Interactions in the HIF SystemExploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish modelsDevelopment of Inhibitors of the PAS-B Domain of the HIF-2α Transcription FactorOn-target efficacy of a HIF-2α antagonist in preclinical kidney cancer modelsEmerging models for the molecular basis of mammalian circadian timingProtein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand bindingDeciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR TransformationThe transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 inductionOn the acquisition and analysis of microscale thermophoresis data.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.Targeting iron metabolism in drug discovery and deliveryIn silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.VHL, the story of a tumour suppressor gene.A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.The role of small molecules in bone regeneration.Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferasePharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growthHypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription.Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectivesIntestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.Hypoxia-inducible factors link iron homeostasis and erythropoiesis.An optogenetic gene expression system with rapid activation and deactivation kinetics.Targeting renal cell carcinoma with a HIF-2 antagonist.Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy.The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.Pheochromocytoma: Gasping for Air.Role of Intestinal HIF-2α in Health and Disease.The role of hypoxia in intestinal inflammation.Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue.The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment.
P2860
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P2860
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@ast
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@en
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@nl
type
label
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@ast
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@en
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@nl
prefLabel
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@ast
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@en
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@nl
P2093
P2860
P3181
P356
P1476
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
@en
P2093
Doug E Frantz
Jacinth Naidoo
Jamie Longgood
Joseph A Garcia
Kevin H Gardner
Richard K Bruick
P2860
P2888
P3181
P356
10.1038/NCHEMBIO.1185
P577
2013-04-01T00:00:00Z
P5875
P6179
1040491797