Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure
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Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Trinucleotide repeats: a structural perspectiveStable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers.Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionInvestigating the structural impact of the glutamine repeat in huntingtin assembly.Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.Examining variable domain orientations in antigen receptors gives insight into TCR-like antibody design.Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis.Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1.Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection.Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity.A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation.Aggregation behavior of chemically synthesized, full-length huntingtin exon1.β-hairpin-mediated nucleation of polyglutamine amyloid formation.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.CCT complex restricts neuropathogenic protein aggregation via autophagy.A toxic mutant huntingtin species is resistant to selective autophagy.A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats.
P2860
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P2860
Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure
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2012 nî lūn-bûn
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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
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2012年論文
@zh-mo
2012年論文
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2012年论文
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name
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@ast
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@en
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
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type
label
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@ast
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@en
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@nl
prefLabel
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@ast
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@en
Disease-Associated Polyglutami ...... gtin Adopt a Compact Structure
@nl
P2093
P2860
P50
P1476
Disease-associated polyglutami ...... gtin adopt a compact structure
@en
P2093
Clare Peters-Libeu
Dean Taylor
Earl Rutenber
Elizabeth Brooks
Karl H Weisgraber
Kartika Widjaja
Kenneth Cheung
Luis A Mosquera
Preethi Krishnan
Siddhartha Mitra
P2860
P304
P356
10.1016/J.JMB.2012.01.034
P407
P577
2012-01-28T00:00:00Z