The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold - Wikidata - awgldk - TriplyDB

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

http://www.wikidata.org/entity/Q27677595

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Animal models for Ebola and Marburg virus infections The Role of Cytokines and Chemokines in Filovirus Infection Crystal Structure of Marburg Virus VP24 The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway Protein stability: a crystallographer's perspective Neglected filoviruses Risks Posed by Reston, the Forgotten Ebolavirus.Could the Ebola virus matrix protein VP40 be a drug target?The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak.The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies Severe fever with thrombocytopenia syndrome virus inhibits exogenous Type I IFN signaling pathway through its NSs invitro A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.Camouflage and misdirection: the full-on assault of ebola virus disease Treatment of ebola virus disease.Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection.Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.Innate immune evasion by filoviruses Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology.Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.Predictive and comparative analysis of Ebolavirus proteins Ebola Virus Infection: Overview and Update on Prevention and Treatment.Insights into Reston virus spillovers and adaption from virus whole genome sequences.Forty-five years of Marburg virus research.Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses.Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.Ebola virus disease: societal challenges and new treatments.Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages.VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.Implications of Toll-like receptors in Ebola infection.Rodent-Adapted Filoviruses and the Molecular Basis of Pathogenesis.Forty Years of Ebolavirus Molecular Biology: Understanding a Novel Disease Agent Through the Development and Application of New Technologies.Host Factors Involved in Ebola Virus Replication.Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging.Filovirus Structural Biology: The Molecules in the Machine.

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The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

http://www.wikidata.org/entity/Q27677595

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2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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The Ebola Virus Interferon Ant ...... nd Has a Novel, Pyramidal Fold

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The Ebola Virus Interferon Ant ...... nd Has a Novel, Pyramidal Fold

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David E Lee

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Sheng Li

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Tong Liu

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Virgil L Woods

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P2860

Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis

Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation

Structural bases of unphosphorylated STAT1 association and receptor binding

Electrostatics of nanosystems: application to microtubules and the ribosome

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

PROCHECK: a program to check the stereochemical quality of protein structures

Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism

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