Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
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Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamilyChemo-Immunotherapeutic Antimalarials Targeting Isoprenoid BiosynthesisSqualene synthase as a target for Chagas disease therapeuticsTaxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate siteDynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate SynthaseResistance-resistant antibiotics3D Structure, Dimerization Modeling, and Lead Discovery by Ligand-protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP).Multitarget drug discovery for tuberculosis and other infectious diseases.Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies.Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometriesIn Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparumRestricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence.Mechanistic aspects of carotenoid biosynthesis.New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.From crystal to compound: structure-based antimalarial drug discovery.Isoprenoid biosynthesis in Plasmodium falciparum.On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge.A new motif for inhibitors of geranylgeranyl diphosphate synthase.Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.Structural and Chemical Biology of Terpenoid Cyclases.Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells.Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.Pyrrolidine-Containing Bisphosphonates as Potential Anti-Resorption Bone Drugs.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.
P2860
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P2860
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@ast
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@en
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@nl
type
label
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@ast
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@en
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@nl
prefLabel
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@ast
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@en
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@nl
P2093
P2860
P3181
P356
P1476
Lipophilic analogs of zoledron ...... t potent antimalarial activity
@en
P2093
Eric Oldfield
Eunhae Lee
Fernando de Macedo Dossin
Jinyoung Anny Yoo
Joo Hwan No
Lucio H Freitas-Junior
Raymond Hui
Xinxin Feng
P2860
P304
P3181
P356
10.1073/PNAS.1118215109
P407
P577
2012-03-13T00:00:00Z