Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
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Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenα(V)β(3) integrin crystal structures and their functional implicationsComplete integrin headpiece opening in eight stepsThree-dimensional reconstruction of intact human integrin IIb 3: new implications for activation-dependent ligand bindingBiology and structure of leukocyte β 2 integrins and their role in inflammationTargeting integrin and integrin signaling in treating thrombosis.αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3The platelet: life on the razor's edge between hemorrhage and thrombosis.RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarctionStructure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligandCommon variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by raceMetal ion and ligand binding of integrin α5β1Translating from the rivers of Babylon to the coronary bloodstreamThree-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin ComplexesDirectly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.αIIbβ3: structure and functionIntegrin αIIbβ3: from discovery to efficacious therapeutic targetA novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.Forget about thrombosis: Platelets and Alzheimer's disease, yet another sticky situation.Novel ecto-tagged integrins reveal their trafficking in live cellsStructural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.
P2860
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P2860
Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@ast
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@en
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@nl
type
label
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@ast
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@en
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@nl
prefLabel
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@ast
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@en
Structure-Guided Design of a H ...... upts Mg2+ Binding to the MIDAS
@nl
P2093
P2860
P3181
P1476
Structure-guided design of a h ...... upts Mg²⁺ binding to the MIDAS
@en
P2093
Barry S Coller
Craig J Thomas
Daniel Bougie
Jianghai Zhu
Jieqing Zhu
Joshua G McCoy
Mark Rasmussen
P2860
P304
P3181
P356
10.1126/SCITRANSLMED.3003576
P407
P577
2012-03-01T00:00:00Z