Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays
about
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationTunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selectionA multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Modifying caspase-3 activity by altering allosteric networks.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
P2860
Q27678026-D0877EC3-7BE0-4EF8-8FDE-85BFECB99139Q27728138-834DFDE2-333D-4EFC-BAA8-96584E6F08D2Q34541773-6C2E7AB6-B1FB-4445-9EA9-4BFD448EA13CQ34680233-5CB71B18-BFAD-4A5B-BCAC-171CE8E5C7A0Q38114942-DBEA940E-E605-46E5-B969-FD6D90C00D08Q48371807-07788FA5-0EB1-49EB-A481-CAE115CD2809Q50918511-66159AE3-4792-41D2-AC13-B4916A4F0B3BQ51763453-744701A2-3A9E-4475-BF29-7A286F3CFA2A
P2860
Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@ast
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@en
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@nl
type
label
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@ast
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@en
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@nl
prefLabel
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@ast
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@en
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@nl
P2093
P2860
P921
P356
P1476
Inhibitory Mechanism of Caspas ...... ations, and Biochemical Assays
@en
P2093
Cheng-Wen Liu
Dai-Fei Liu
Lan-Fen Li
Xiao-Dong Su
Xiao-Jun Wang
Yi-Qin Gao
P2860
P304
P356
10.1074/JBC.M112.351213
P407
P577
2012-05-04T00:00:00Z