Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid

Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid

Item
http://www.wikidata.org/entity/Q27678291
Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening MethodologiesA tale of two drug targets: the evolutionary history of BACE1 and BACE2BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseAdvances in the identification of β-secretase inhibitors.BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.A perspective on multi-target drug discovery and design for complex diseases.
P2860

Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid

Item
http://www.wikidata.org/entity/Q27678291
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Design and preparation of a po ...... reduction of central β-amyloid
@ast
Design and preparation of a po ...... reduction of central β-amyloid
@en
Design and preparation of a po ...... reduction of central β-amyloid
@nl
type
label
Design and preparation of a po ...... reduction of central β-amyloid
@ast
Design and preparation of a po ...... reduction of central β-amyloid
@en
Design and preparation of a po ...... reduction of central β-amyloid
@nl
prefLabel
Design and preparation of a po ...... reduction of central β-amyloid
@ast
Design and preparation of a po ...... reduction of central β-amyloid
@en
Design and preparation of a po ...... reduction of central β-amyloid
@nl
P1433
P1476
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P3181
P356
P1433
P1476
Design and preparation of a po ...... reduction of central β-amyloid
@en
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698