Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase
about
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymesCatalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionalityTargeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammationEnzyme Tunnels and Gates As Relevant Targets in Drug Design.Parasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasisPeptide POP inhibitors for the treatment of the cognitive symptoms of schizophrenia.Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors.Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interactionNDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness.Analyzing slowly exchanging protein conformations by ion mobility mass spectrometry: study of the dynamic equilibrium of prolyl oligopeptidase.Unveiling prolyl oligopeptidase ligand migration by comprehensive computational techniques.Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation.Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometryFibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach.Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics.Prolyl oligopeptidase-like deficient Trypanosoma evansi parasites are associated with reduced interleukin-10 concentrations in vivo and in vitro
P2860
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P2860
Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@ast
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@en
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@nl
type
label
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@ast
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@en
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@nl
prefLabel
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@ast
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@en
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@nl
P2093
P50
P1433
P1476
Molecular dynamics, crystallog ...... anism of prolyl oligopeptidase
@en
P2093
J-F St Pierre
Jyrki Hokkanen
Karol Kaszuba
Reinis Danne
Tünde Juhász
Vilmos Fülöp
Zoltán Szeltner
P304
P356
10.1016/J.BIOCHI.2012.03.012
P577
2012-06-01T00:00:00Z