about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesStructure-function studies of DNA polymerase λA new paradigm of DNA synthesis: three-metal-ion catalysis.Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.The E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide SelectionStructural Basis for Promutagenicity of 8-Halogenated GuanineStructures of the Leishmania infantum polymerase betaMetal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase βTransition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanineVisualizing phosphodiester-bond hydrolysis by an endonucleaseCrystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complexCapture of a third Mg²⁺ is essential for catalyzing DNA synthesisA fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dGStructures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity MechanismOxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repairTCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cellsStructure and mechanism of DNA polymerase βAn overview of Y-Family DNA polymerases and a case study of human DNA polymerase ηRevealing the role of the product metal in DNA polymerase β catalysis.Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.RB69 DNA polymerase structure, kinetics, and fidelity.Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acidsStructural basis for the D-stereoselectivity of human DNA polymerase β.Quantum mechanical analysis of nonenzymatic nucleotidyl transfer reactions: kinetic and thermodynamic effects of β-γ bridging groups of dNTP substratesPhosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantUltrafast water dynamics at the interface of the polymerase-DNA binding complexStructural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase βStructure and function of TatD exonuclease in DNA repair.Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β.Substrate-induced DNA polymerase β activation.Recognition and repair of chemically heterogeneous structures at DNA endsUncovering the polymerase-induced cytotoxicity of an oxidized nucleotideEffects of DNA3'pp5'G capping on 3' end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance.Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent CrystallographyNew structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis.Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Observing a DNA Polymerase Choose Right from Wrong
@ast
Observing a DNA Polymerase Choose Right from Wrong
@en
Observing a DNA Polymerase Choose Right from Wrong
@nl
type
label
Observing a DNA Polymerase Choose Right from Wrong
@ast
Observing a DNA Polymerase Choose Right from Wrong
@en
Observing a DNA Polymerase Choose Right from Wrong
@nl
prefLabel
Observing a DNA Polymerase Choose Right from Wrong
@ast
Observing a DNA Polymerase Choose Right from Wrong
@en
Observing a DNA Polymerase Choose Right from Wrong
@nl
P2093
P2860
P3181
P1433
P1476
Observing a DNA polymerase choose right from wrong
@en
P2093
Bret D Freudenthal
David D Shock
William A Beard
P2860
P304
P3181
P356
10.1016/J.CELL.2013.05.048
P407
P577
2013-07-01T00:00:00Z