P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

Item
http://www.wikidata.org/entity/Q27679177
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIVThermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteasesA Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413Highly resistant HIV-1 proteases and strategies for their inhibition.C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including DarunavirRecent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDSGRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2' -Abt-containing HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant varianMechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid
P2860

P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

Item
http://www.wikidata.org/entity/Q27679177
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@ast
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@en
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@nl
type
label
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@ast
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@en
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@nl
prefLabel
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@ast
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@en
P2' Benzene Carboxylic Acid Mo ...... P2 bis-Tetrahydrofuran Moiety
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
P2' benzene carboxylic acid mo ...... P2 bis-tetrahydrofuran moiety
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932