Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability - Wikidata - awgldk - TriplyDB

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

http://www.wikidata.org/entity/Q27679266

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HDAC inhibitors and immunotherapy; a double edged sword?Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2 Light-controlled modulation of gene expression by chemical optoepigenetic probes Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers Valproic acid as a potential inhibitor of Plasmodium falciparum histone deacetylase 1 (PfHDAC1): an in silico approach.Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.Computational design of a time-dependent histone deacetylase 2 selective inhibitor.Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor.Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors.Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution Natural products as zinc-dependent histone deacetylase inhibitors.Structure and function insights into the NuRD chromatin remodeling complex.Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.Epigenetic modulation of dental pulp stem cells: implications for regenerative endodontics.Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism.Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients.Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.The effect of metalloprotein inhibitors on cellular metal ion content and distribution.Curcumin and hydroxamate-derivative (PCI-34058) interfere with histone deacetylase I catalytic core Asp-His charge relay system: atomistic simulation studies.Translating HDAC inhibitors in Friedreich's ataxia.HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.Drug-Target Kinetics in Drug Discovery.In-silico profiling of the biological activities of Amaryllidaceae alkaloids.Chemical optogenetic modulation of inflammation and immunity.Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.Scaffold dependent histone deacetylase (HDAC) inhibitor induced re-equilibration of the subcellular localization and post-translational modification state of class I HDACs The IGF signalling pathway in Wilms tumours--a report from the ENCCA Renal Tumours Biology-driven drug development workshop.Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective Chemotherapy against Neurological Disorders.The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity.

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

http://www.wikidata.org/entity/Q27679266

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Histone Deacetylase (HDAC) Inh ...... anscription and Cell Viability

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Histone Deacetylase (HDAC) Inh ...... anscription and Cell Viability

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Histone Deacetylase (HDAC) Inh ...... anscription and Cell Viability

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Histone Deacetylase (HDAC) Inh ...... anscription and Cell Viability

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JBC.M113.490706

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Journal of Biological Chemistry

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Histone Deacetylase (HDAC) Inh ...... anscription and Cell Viability

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Allegra Ritscher

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Benjamin E L Lauffer

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Birgit Flicke

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Christine Tam

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Christopher E Heise

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Daniel F Ortwine

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Grazyna Fedorowicz

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Inna Zilberleyb

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Janet Gunzner

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Joshua S Kaminker

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Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers

An epigenetic blockade of cognitive functions in the neurodegenerating brain

A decade of exploring the cancer epigenome - biological and translational implications

Combinatorial patterns of histone acetylations and methylations in the human genome

MolProbity: all-atom structure validation for macromolecular crystallography

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

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26926-43

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10.1074/JBC.M113.490706

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37

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288

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Christopher M Koth

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2013-09-13T00:00:00Z

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23897821

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