Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis - Wikidata - awgldk - TriplyDB

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis Resistance to antibiotics targeted to the bacterial cell wall Core Steps of Membrane-Bound Peptidoglycan Biosynthesis: Recent Advances, Insight and Opportunities Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.Structural basis for catalysis at the membrane-water interface.Analysis of MreB interactors in Chlamydia reveals a RodZ homolog but fails to detect an interaction with MraY Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine.Proposed carrier lipid-binding site of undecaprenyl pyrophosphate phosphatase from Escherichia coli.Analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate.Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays.Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway Improving the N-terminal diversity of sansanmycin through mutasynthesis.Structure-function relationships of membrane-associated GT-B glycosyltransferases.The giant protein Ebh is a determinant of Staphylococcus aureus cell size and complement resistance.A Modular Approach to Phosphoglycosyltransferase Inhibitors Inspired by Nucleoside Antibiotics.New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies.N-Acetylglucosamine-1-phosphate transferase, WecA, as a validated drug target in Mycobacterium tuberculosis.Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.Targeting the gram-negative bacteria peptidoglycan synthase MraY as a new approach for monoclonal antibody anti-bacterial activity.Membrane Interaction of the Glycosyltransferase WaaG.TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes.Ligand Shaping in Induced Fit Docking of MraY Inhibitors. Polynomial Discriminant and Laplacian Operator as Biological Activity Descriptors.Structural Investigation of Park's Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors.Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY.Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174.Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams.Quinovosamycins: new tunicamycin-type antibiotics in which the α, β-1″,11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine.Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactams.Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface.

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

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Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis

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Ben C Chung

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Do-Yeon Kwon

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Jinshi Zhao

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Jiyong Hong

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Robert A Gillespie

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Seok-Yong Lee

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Ziqiang Guan

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P2860

PHENIX: a comprehensive Python-based system for macromolecular structure solution

A short history of SHELX

Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

Purification and characterization of the bacterial MraY translocase catalyzing the first membrane step of peptidoglycan biosynthesis.

A high-throughput, homogeneous, fluorescence resonance energy transfer-based assay for phospho-N-acetylmuramoyl-pentapeptide translocase (MraY).

MraY Inhibitors as Novel Antibacterial Agents.

Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins.

The biosynthesis of peptidoglycan lipid-linked intermediates.

Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis.

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