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Discovery of new enzymes and metabolic pathways by using structure and genome context

Discovery of new enzymes and metabolic pathways by using structure and genome context

http://www.wikidata.org/entity/Q27680014

about

Leveraging structure for enzyme function prediction: methods, opportunities, and challenges Substrate Deconstruction and the Nonadditivity of Enzyme Recognition Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases PINGU: PredIction of eNzyme catalytic residues usinG seqUence information Paracoccus denitrificans possesses two BioR homologs having a role in regulation of biotin metabolism Development of bio-based fine chemical production through synthetic bioengineering Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative.Docking Screens for Novel Ligands Conferring New Biology.Assessment of genome annotation using gene function similarity within the gene neighborhood.The evolution of enzyme function in the isomerases.An atypical orphan carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis.Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.Structure-based virtual screening for drug discovery: principles, applications and recent advances.Predicting the functions and specificity of triterpenoid synthases: a mechanism-based multi-intermediate docking approach.DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe.De novo assembly and functional annotation of Myrciaria dubia fruit transcriptome reveals multiple metabolic pathways for L-ascorbic acid biosynthesis L-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.Enzyme recruitment and its role in metabolic expansion.Profiling the orphan enzymes.Functional genomics of tomato: opportunities and challenges in post-genome NGS era.Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle.Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis.Optimizing genome-scale network reconstructions.Dissect new mechanistic insights for geniposide efficacy on the hepatoprotection using multiomics approach.Prediction of enzymatic pathways by integrative pathway mapping.Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.Stress-responsively modulated ymdAB-clsC operon plays a role in biofilm formation and apramycin susceptibility in Escherichia coli.Enzyme fusion for whole-cell biotransformation of long-chain sec-alcohols into esters.Metabolism: digging up enzyme functions.Pelagibaca bermudensis promotes biofuel competence of Tetraselmis striata in a broad range of abiotic stressors: dynamics of quorum-sensing precursors and strategic improvement in lipid productivity.Crius: A novel fragment-based algorithm of de novo substrate prediction for enzymes Gene Gangs of the Chloroviruses: Conserved Clusters of Collinear Monocistronic Genes

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Discovery of new enzymes and metabolic pathways by using structure and genome context

http://www.wikidata.org/entity/Q27680014

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Discovery of new enzymes and metabolic pathways by using structure and genome context

@ast

Discovery of new enzymes and metabolic pathways by using structure and genome context

@en

Discovery of new enzymes and metabolic pathways by using structure and genome context

@nl

type

label

Discovery of new enzymes and metabolic pathways by using structure and genome context

@ast

Discovery of new enzymes and metabolic pathways by using structure and genome context

@en

Discovery of new enzymes and metabolic pathways by using structure and genome context

@nl

prefLabel

Discovery of new enzymes and metabolic pathways by using structure and genome context

@ast

Discovery of new enzymes and metabolic pathways by using structure and genome context

@en

Discovery of new enzymes and metabolic pathways by using structure and genome context

@nl

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B McKay Wood

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Brandan S Hillerich

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Jeffery B Bonanno

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John A Gerlt

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Matthew W Vetting

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Ronald D Seidel

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Shoshana Brown

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P2860

Annotation error in public databases: misannotation of molecular function in enzyme superfamilies

MAFFT version 5: improvement in accuracy of multiple sequence alignment

The Enzyme Function Initiative.

Structure-based activity prediction for an enzyme of unknown function

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli

Prediction and assignment of function for a divergent N-succinyl amino acid racemase

Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase

Coot: model-building tools for molecular graphics

Protein production by auto-induction in high density shaking cultures

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10.1038/NATURE12576

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